Treatments for Depression for Older Adults Living in Long-Term Care: A Systematic Review and Network Meta-Analysis.

Objective: To assess the comparative efficacy of interventions on depressive symptoms and disorders in older adults living in long-term care (LTC).

Design: Systematic review and network meta-analysis.

Setting And Participants: Older adults living in LTC or equivalent settings.

Canadian Clinical Guidelines on Social Isolation and Loneliness in Older Adults.

Background: Preventing and addressing social isolation and loneliness among older adults is important because of the known associations with negative health outcomes. The Canadian Coalition for Seniors' Mental Health (CCSMH) took on the task of creating clinical guidelines.

Method: A multidisciplinary working group was established.

A Comprehensive Review of the Botany, Bioactive Compounds and Health Benefits of Leptospermum.

There is increasing interest in research and application of natural bioactive compounds due to the growing demand for functional ingredients from the pharmaceutical, cosmetic and food industries. A major challenge is finding suitable natural plant resources for the development of functional ingredients. Leptospermum, a genus of the myrtle family (Myrtaceae), is primarily native to Australia.

Effectiveness of geriatric rehabilitation in inpatient and day hospital settings: a systematic review and meta-analysis.

Background: Geriatric rehabilitation is a multidisciplinary intervention that promotes functional recovery in older adults. Our objective was to assess the efficacy of geriatric rehabilitation in inpatient and geriatric day hospital settings.

Methods: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, PEDro and AgeLine from inception to September 30, 2022 for randomized controlled trials (RCTs) including older adults (age ≥ 65 years) undergoing geriatric rehabilitation (inpatient or day hospital) with a usual care comparator group.

Amelioration of Cancer Cachexia by Extract Through AKT Signaling Pathway Regulation.

Cancer cachexia is a multifactorial syndrome characterized by the progressive loss of skeletal muscle mass and adipose tissue. is widely used in traditional medicine in Korea and China to treat various diseases. However, its exact role and underlying mechanism in regulating cancer cachexia have not been elucidated yet.