Publications by authors named "P Lasko"
Article Synopsis
- EpCAM and Trop2 are cell surface markers linked to carcinoma, affecting myosin-based cell behaviors essential for adhesion and migration, but their specific roles in cancer metastasis are not well understood.
- The study uses MCF7 breast cancer cell spheroids to explore how different levels of EpCAM and Trop2 influence cell spreading and cohesion, revealing that depleting EpCAM promotes spreading while depleting Trop2 inhibits it.
- The findings suggest that EpCAM and Trop2 work together to regulate cell contractility and adhesion by affecting cortical tension at cell interfaces, indicating their potential function as a mechanostat that modulates cell behavior in cancer progression.
Article Synopsis
- In biomedical research for rare diseases, model organisms are essential for understanding disease mechanisms, identifying biomarkers, and developing therapies.
- Solve-RD is an EU-funded project focused on addressing numerous previously unresolved rare diseases.
- The project has led to the creation of the European Rare Disease Models & Mechanisms Network (RDMM-Europe) to enhance research efforts in this area.
mRNA translation is a fundamental process for life. Selection of the translation initiation site (TIS) is crucial, as it establishes the correct open reading frame for mRNA decoding. Studies in vertebrate mRNAs discovered that a purine at -3 and a G at +4 (where A of the AUG initiator codon is numbered + 1), promote TIS recognition.
View Article and Find Full Text PDFDrosophila sperm development is characterized by extensive post-transcriptional regulation whereby thousands of transcripts are preserved for translation during later stages. A key step in translation initiation is the binding of eukaryotic initiation factor 4E (eIF4E) to the 5' mRNA cap. In addition to canonical eIF4E-1, Drosophila has multiple eIF4E paralogs, including four (eIF4E-3, -4, -5, and -7) that are highly expressed in the testis.
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