Publications by authors named "P Lampe"
Article Synopsis
- - Carbohydrate antigen 19-9 (CA19-9) is a clinically established biomarker for pancreatic ductal adenocarcinoma (PDAC) but is not very effective for early detection, prompting the exploration of circulating miRNAs in plasma as potential early biomarkers.
- - A study analyzed 2083 miRNAs from patients and healthy controls, identifying a three-miRNA signature (let-7i-5p, miR-130a-3p, and miR-221-3p) that effectively distinguished early-stage PDAC from healthy individuals and chronic pancreatitis, showing improved accuracy when combined with CA19-9.
- - The miRNA signature demonstrated high predictive accuracy in various stages of the disease and
Background: Cardiac arrhythmias are the main cause of sudden death due to Chronic Chagasic Cardiomyopathy (CCC). Here we investigated alterations in connexin 43 (Cx43) expression and phosphorylation in cardiomyocytes as well as associations with cardiac arrhythmias in CCC.
Methods: C57Bl/6 mice infected with underwent cardiac evaluations at 6 and 12 months after infection via treadmill testing and EKG.
Article Synopsis
- Mitochondrial fusion and fission are vital for stress responses and managing metabolic changes, which involves the protein Opa1 in its various forms.
- The study involved creating mouse models with specific Opa1 isoforms to determine their role, showing that both cleavable and non-cleavable forms support embryo and adult mouse health.
- Opa1 processing isn't essential for dealing with metabolic or thermal stress but is crucial for longevity and heart health in mice with faulty energy production, indicating its importance in regulating heart growth and metabolism.
Proteolysis targeting chimeras (PROTACs) are new chemical modalities that degrade proteins of interest, including established kinase targets and emerging RNA-binding proteins (RBPs). Whereas diverse sets of biochemical, biophysical and cellular assays are available for the evaluation and optimizations of PROTACs in understanding the involved ubiquitin-proteasome-mediated degradation mechanism and the structure-degradation relationship, a phenotypic method profiling the cellular morphological changes is rarely used. In this study, first, we reported the only examples of PROTACs degrading the mRNA-binding protein YTHDF2 via screening of multikinase PROTACs.
View Article and Find Full Text PDFCombination of modified FOLFIRINOX with stereotactic body radiotherapy as an induction therapy for locally advanced pancreatic adenocarcinoma - a prospective single-arm study.
Contemp Oncol (Pozn)
March 2024
Introduction: Radical resection is the only potentially curative treatment for pancreatic adenocarcinoma; however, only a minor fraction of patients are eligible for resection. Induction therapy may be offered to patients, but the response rate in cases with significant vascular involvement is limited. This study aimed to evaluate the efficacy and safety of modified of FOLFIRINOX chemotherapy (mFFX) + stereotactic body radiotherapy (SBRT) in combination as induction therapy for locally advanced pancreatic carcinoma.
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