Modulation of the Th1/Th2 bias by an immunoglobulin histamine complex in the ovalbumin allergy mouse model.

Vaccination with the antiallergic drug Histaglobin is used to treat a broad range of human allergic diseases including bronchial asthma, allergic rhinitis, and atopic dermatitis. In order to further elucidate its functional activity, Histaglobin was investigated in an in vivo mouse allergy model. Mice were sensitized with ovalbumin either prior to or after Histaglobin treatment, and its antiallergic potential was evaluated.

[Pharmacokinetic study of a new benzyl-1 isoquinoline derivative (458 L) after oral administration in men].

Pharmacokinetic study of 458 L. via oral route, was performed in twelve normal volunteers, in a randomized crossover design of three galenic forms. Plasma concentrations were determined, after extraction, by HPLC, with spectrofluorimetric detection.

Studies on the immunostimulating and anti-tumour activity of a fraction isolated from Corynebacterium granulosum.

The immunostimulating activity of the anaerobic corynebacteriae is well documented. Fractions isolated from while cells have not been much investigated. We have reported that the immunostimulating activity is present in fractions isolated from Corynebacterium granulosum.