Glucagon, ureteral colic and ureteral peristalsis.

Experimentally, glucagon is an effective ureteral relaxant that induces a moderate diuresis. Our data suggest that in specified cases of ureteral colic, before the development of a ureteral bar, flaccid dilatation of the pelvis and renal shutdown, glucagon may facilitate the expulsion of small ureteral calculi. When the ureteral pain is due to hyperperistalsis the drug has promise in the alleviation of pain.

Ureteral function. IV. The urometrogram at increased urine output.

In this study the shape of the urometrogram or ureteral pressure pulse is evaluated as a function of urine output. Using a simultaneous monitoring technique, the urometrogram, spurt volume, and wave speed, as well as various aspects of wave geometry, have been studied on dogs with explanted bladders during various stages of urine output. The qualitative shape of the urometrogram is discussed for urine flows ranging from less than 0.

Current status of the urethral pressure profile as a urodynamic test.

The urethral pressure profile is a manipulation test of the bladder neck, urethra, and its sphincters. It measures the balance of pressure at each point along the urethra while a small amount of distending fluid is instilled continuously. The urethral pressure profile probably represents a perfusion pressure, a minimal distension pressure, or a minimal opening pressure that is altered by the caliber of the urethra and the compliance of its walls along its proximal course.

Computer evaluation of the effect of urecholine on the spontaneous activity of smooth muscle from the urinary bladder of the rabbit.

The spontaneous activity exhibited in vitro by smooth muscle strips from the urinary bladder of the rabbit under the influence of Urecholine in concentrations from 0.3 to 30 muM has been characterized in terms of three parameters: mean tension, frequency of contraction, and contractile deviation, all obtained by computer an alysis. While mean tension and frequency monotonically increased with concentration, the contractile deviation rose to a peak in the vicinity of 3.