Publications by authors named "P LE BAYON"
Article Synopsis
- Metal-based chemotherapeutics, particularly cisplatin, are commonly used for cancer treatment, but researchers are exploring alternatives like copper (Cu) complexes to reduce side effects.
- A study focused on enhancing a Cu(II) compound known for its ability to generate reactive oxygen species (ROS), by adding functional groups that improve solubility and cellular uptake without altering its core redox activity.
- Results showed that while some modifications didn't enhance cytotoxicity, using cell-penetrating peptides significantly improved the anticancer effectiveness of the Cu(II) complex and ensured better delivery into cells, suggesting potential strategies for developing more effective cancer treatments.
Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria infection (CHMI) with the same parasites as in the vaccine (homologous) than with genetically distant parasites (heterologous). We sought to identify an immunization regimen that provided similar VE against CHMI with homologous and heterologous Pf for at least 9 weeks in malaria-naïve adults. Such a regimen was identified in part 1 (optimization), an open label study, and confirmed in part 2 (verification), a randomized, double-blind, placebo-controlled study in which VE was assessed by cross-over repeat CHMI with homologous (PfNF54) and heterologous (Pf7G8) PfSPZ at 3 and 9-10 weeks.
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- The study focuses on new Pt(II) complexes made from semisquaraine-type ligands, detailing their synthesis, characterization, and potential as cancer treatments.
- Eight new ligands were created using a simple method, and their structures were confirmed through advanced techniques like NMR and X-ray diffraction, as well as theoretical calculations.
- The complexes exhibit strong photoactivity and improved solubility in biological environments, showing enhanced cytotoxic effects on various cancer cell lines, including those resistant to cisplatin, especially after photoactivation.
The synthesis and characterization of four platinum(II) complexes using azobenzenes conveniently functionalized as ligands has been carried out. The characteristic photochemical behavior of the complexes due to the presence of azobenzene-type ligands and the role of the ligands in the activation of the complexes has been studied. Their promising cytotoxicity observed in HeLa cells prompted us to study the mechanism of action of these complexes as cytostatic agents.
View Article and Find Full Text PDFThree novel dinuclear Cu(II) complexes based on a ,,-chelating salphen-like ligand scaffold and bearing varying aromatic substituents (-H, -Cl, and -Br) have been synthesized and characterized. The experimental and computational data obtained suggest that all three complexes exist in the dimeric form in the solid state and adopt the same conformation. The mass spectrometry and electron paramagnetic resonance results indicate that the dimeric structure coexists with the monomeric form in solution upon solvent (dimethyl sulfoxide and water) coordination.
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