Streptococcus pneumoniae endophthalmitis after exposed glaucoma drainage implant.

A patient with juvenile glaucoma status post 2 glaucoma drainage implants in each eye presents with painful vision loss in the left eye and is found to have streptococcus pneumoniae endophthalmitis from an exposed inferior glaucoma drainage implant. The infection is managed medically with intravitreal antibiotics and surgically with a glaucoma drainage device revision, anterior chamber washout and pars plana vitrectomy.

Bleb leak revision with Tenon's autograft.

This video demonstrates two surgical cases where autologous Tenon grafts are used to shut down leaking trabeculectomies. Variations in this technique with a rotational graft and a hinge graft are explored.

TNO155 is a selective SHP2 inhibitor to target -dependent oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is known to be driven by multiple intricated receptor tyrosine kinases (RTKs) including EGFR, PI3K/AKT and MAPK signaling pathways. However, whilst targeting EGFR with cetuximab has been approved for the treatment of OSCC, other single-agent inhibitors of the RTKs have shown modest effects in improving survival. From the genome-wide CRISPR/Cas9 screen on 21 OSCC cell lines, we have identified among the top essential genes in OSCC.

Tuberculous Otomastoiditis: A Diagnostic Dilemma.

Where tuberculous (TB) infection is prevalent, the diagnosis of TB otomastoiditis (TOM) should be considered in a chronically discharging ear that does not respond to standard medical treatment. We are reporting a case of TB otomastoiditis with an adjacent deep neck abscess in a healthy 18-year-old male. He presented with a five five-month history of right otorrhea with hearing loss and a concurrent right level two neck swelling, without any signs of acute infection.