Publications by authors named "P L Siqueira"
APX2009 sensitizes hypoxic breast cancer cells to doxorubicin by increasing its accumulation and caspase-3/7-mediated apoptosis.
Breast Cancer Res Treat
October 2024
Purpose: The association of targeted therapy with chemotherapy is encouraged to increase the treatment efficiency, especially in hypoxic triple-negative breast cancer. The APE1 redox activity has stood out as a potential tumor target. However, the effect of the association of the APE1 redox inhibitors with doxorubicin in hypoxia still needs to be evidenced.
View Article and Find Full Text PDFPurpose: Bioactive molecules are relevant to fight cancer and associated conditions. Quinoxaline is a privileged N-heterocycle, notably as anticancer agents. Herein, we report the evaluation of the quinoxaline derivatives DEQX and OAQX as anticancer agents, as well as in function of their anti-inflammatory and analgesic activities.
View Article and Find Full Text PDFUnbalanced redox status and constitutive STAT3 activation are related to several aspects of tumor biology and poor prognosis, including metastasis and drug resistance. The triple-negative breast cancer (TNBC) is listed as the most aggressive and exhibits the worst prognosis among the breast cancer subtypes. Although the mechanism of reactive oxygen species (ROS) generation led to STAT3 activation is described, there is no data concerning the STAT3 influence on redox homeostasis in TNBC.
View Article and Find Full Text PDFApurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/REF-1) is a multifunctional protein acting on cellular signaling pathways, including DNA repair and redox activities. APE1/REF-1 has emerged as a target for cancer therapy, and its role in breast cancer models would reveal new strategies for cancer therapy. APX2009 is a specific APE1/REF-1 redox inhibitor whose anticancer properties have not been described in breast cancer cells.
View Article and Find Full Text PDFArticle Synopsis
- - Mitochondrial dysfunction contributes to various diseases by reducing energy production and increasing harmful byproducts, leading to cell death signals.
- - Photobiomodulation (PBM) is a noninvasive treatment using low-energy light to potentially improve cellular function and has shown promise in addressing mitochondrial dysfunction linked to neurodegenerative and metabolic disorders.
- - Research indicates that low-power lasers (LPL) and light-emitting diodes (LED) may enhance mitochondrial dynamics and serve as effective therapeutic options for conditions like Alzheimer's, diabetes, and other health issues associated with dysfunctional mitochondria.