Microcephaly protein ANKLE2 promotes Zika virus replication.

Orthoflaviviruses are positive-sense single-stranded RNA viruses that hijack host proteins to promote their own replication. Zika virus (ZIKV) is infamous among orthoflaviviruses for its association with severe congenital birth defects, notably microcephaly. We previously mapped ZIKV-host protein interactions and identified the interaction between ZIKV non-structural protein 4A (NS4A) and host microcephaly protein ankyrin repeat and LEM domain-containing 2 (ANKLE2).

Clinical and molecular analysis of ESBL, carbapenemase, and colistin-resistant bacteria in UTI patients.

Uropathogens, particularly bacteria, can infect any part of the urinary tract and cause bacteriuria. Our study aimed to examine the antibiotic-resistant profile, associated risk factors, and phenotypic and genotypic features of ESBL, carbapenemase, and mcr resistance genes in multidrug-resistant bacteria. Samples were inoculated on culture media, identified using standard biochemical tests, and species confirmation was performed via 16S rRNA gene amplification.

Tracking the Ghosts of the Himalayas: Snow Leopard Conservation Insights From Satellite Collar Data.

This study presents the first movement analysis of snow leopards () using satellite telemetry data, focusing on the northeastern Himalayas of Nepal. By examining GPS-based satellite collar data between 2013 and 2017 from five collared snow leopards (effectively three individuals), the research uncovered distinct movement patterns, activity budgeting and home range utilisation from one adult male and two sub adult females. Hidden Markov models (HMMs) revealed three behavioural states based on the movement patterns-slow (indicative of resting), moderate and fast (associated with travelling) and demonstrated that the time of day influenced their behavioural state.

Epigenetic Role of Long Non-coding RNAs in Multiple Myeloma.

Purpose Of The Review: This review aims to explore the pivotal role of long non-coding RNAs (lncRNAs) as epigenetic regulators in the pathogenesis of multiple myeloma (MM). Additionally, we have portrayed the dual role of lncRNAs in the epigenetic landscape of MM pathobiology.

Recent Findings: In MM, lncRNAs are pivotal for proliferation, progression, and drug resistance by acting as miRNA sponges, regulating mRNA activity through microRNA recognition elements (MREs).