Publications by authors named "P L Rady"
Article Synopsis
- - Tirbanibulin 1% ointment, approved by the EU in 2021, is used to treat actinic keratoses and has shown effectiveness against various HPV-related lesions and cancers.
- - A study on HeLa cells treated with tirbanibulin revealed that it inhibits cell proliferation with an IC of 31.49 nmol/L, downregulating multiple key proteins involved in cancer progression and cell cycle regulation.
- - The findings suggest that tirbanibulin affects HPV oncoprotein expression and activates apoptotic pathways, indicating a potential mechanism for its antiproliferative effects.
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with high rates of metastasis and mortality. In vitro studies suggest that selinexor (KPT-330), an inhibitor of exportin 1, may be a targeted therapeutic option for MCC. This selective inhibitor prevents the transport of oncogenic mRNA out of the nucleus.
View Article and Find Full Text PDFTrichodysplasia spinulosa (TS) is a rare, disfiguring skin condition which presents with widespread asymptomatic or pruritic, skin-colored papules with white protruding keratin spiculations in immunocompromised individuals. Due to its rarity, there is little data to guide treatment decisions. The purpose of this article is to report a case of TS that completely resolved after treatment with topical cidofovir.
View Article and Find Full Text PDFBackground: Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine cutaneous carcinoma aetiologically linked to the Merkel cell polyomavirus (MCPyV). Immune checkpoint inhibitors are currently the first-line therapy for metastatic MCC; however, the treatment is effective in only about half of patients, highlighting the need for alternative therapies. Selinexor (KPT-330) is a selective inhibitor of nuclear exportin 1 (XPO1) and has been shown to inhibit MCC cell growth in vitro, but the pathogenesis has not been established.
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