Publications by authors named "P L Pearson"
's inosine-5'-monophosphate dehydrogenase (IMPDH, GuaB encoded by the gene) is a potential therapeutic target. GuaB is necessary for replication in mammalian hosts but not in standard laboratory culture conditions. Therefore, we cannot test novel GuaB inhibitors against without utilizing mammalian infection models.
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- Non-muscle myosin II (NMII) plays a crucial role in biological processes, but current therapeutic options are limited due to non-selective inhibitors like blebbistatin that affect both NMII and cardiac myosin II (CMII).
- Researchers developed a series of selective NMII inhibitors, notably MT-228, which demonstrates high brain penetration and effectiveness in preclinical models for stimulant use disorder, a condition lacking FDA-approved treatments.
- The structure of MT-228 binding to myosin II reveals its 17-fold selectivity for NMII over CMII, providing insights for future drug development and potential applications in various medical fields, including cancer and nerve regeneration.
Skin injury: Associations with variables related to perfusion and pressure.
Anaesth Intensive Care
November 2024
Article Synopsis
- Skin injuries, particularly hospital-acquired pressure injuries (HAPIs), pose a significant challenge in critically ill patients, and the study examined how perfusion-related factors might contribute to these injuries.
- The study involved 533 adult patients in an intensive care unit, analyzing the relationship between various perfusion factors (like vasopressor use and mechanical circulatory support) and the risk of developing HAPIs compared to immobility factors such as long-term mechanical ventilation.
- Results indicated that perfusion-related issues are more strongly associated with skin injury risk than immobility, suggesting that understanding these factors could lead to new treatment and prevention strategies for skin injuries in critically ill patients.
Recent changes in climate and human land-use have resulted in alterations of the geographic range of many species, including human pathogens. Geographic range expansion and population growth of human pathogens increase human disease risk. Relatively little empirical work has investigated the impact of range changes on within-population variability, a contributor to both colonization success and adaptive potential, during the precise time in which populations are colonized.
View Article and Find Full Text PDFObjective: Here we report our preclinical, proof-of-concept testing to assess the ability of a novel device to correct mitral regurgitation. The Milwaukee Heart device aims to enable any cardiac surgeon to perform high-quality mitral valve repair using a standard annuloplasty ring with a crosshatch of microporous, monofilament suture.
Methods: Hemodynamic, echocardiographic, and videographic data were collected at baseline, following induction of mitral regurgitation, and after repair using porcine hearts in an ex vivo biosimulator model.