Publications by authors named "P L Pearl"
Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity. These characteristics make it particularly challenging to establish their targeted therapies, and many of the IMEs are treated nowadays only symptomatically and supportively.
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- In drug-resistant epilepsy, the study focuses on using deep learning to analyze intracranial electroencephalography (iEEG) signals, specifically through time-frequency (TF) images, to locate the epileptogenic zone (EZ) for surgical guidance.
- The researchers processed iEEG data from 20 children and employed a pre-trained neural network (VGG16) to measure visual complexity, revealing that contacts within the seizure onset zone had significantly lower activation energy compared to those outside.
- The findings suggest a new computer-assisted method for accurately localizing the EZ with a 7 mm accuracy in MRI scans, potentially reducing the need for extensive manual iEEG examinations.
Creative thinking represents one of our highest-order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our adaptation and survival.
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- The study investigates the role of spike-ripple onset overlap (SRO) as a potential biomarker for identifying the epileptogenic focus in patients with drug-resistant epilepsy.
- SRO demonstrated higher specificity and precision in predicting successful surgical outcomes compared to other commonly used markers, indicating its clinical significance.
- The findings support the idea that identifying and targeting SRO could lead to better treatment strategies and reduced need for extended monitoring in epilepsy patients.