Publications by authors named "P L Ordonez"
Lung cancer is the primary cause of cancer-related deaths. Most patients are typically diagnosed at advanced stages. Low-dose computed tomography (LDCT) has been proven to reduce lung cancer mortality, but screening programs using LDCT are associated with a high number of false positives and unnecessary thoracotomies.
View Article and Find Full Text PDFNeisseria gonorrhoeae exhibits alarming antibiotic resistance trends and poses a significant challenge in therapeutic management. This study aimed to explore the association of penA alleles with penicillin-binding protein (PBP) occupancy patterns and reduced outer membrane permeability, impacting susceptibility to last-line cephalosporins and potential β-lactam candidates. The whole genome sequence, the MICs and PBP IC50s were determined for 12 β-lactams and β-lactamase inhibitors in 8 clinical isolates with varying β-lactam sensitivity, 2 ATCC, and 3 WHO cephalosporin-resistant reference strains.
View Article and Find Full Text PDFArticle Synopsis
- Acute pancreatitis (AP) is an inflammatory condition with various causes, including drugs, which account for a small percentage of cases; diagnosing drug-induced AP is often complicated due to a lack of specific symptoms.
- A study conducted at Hospital Universitari de Bellvitge analyzed 38 patients with suspected drug-induced AP from June 2007 to March 2023, revealing that most cases were linked to a single drug, with azathioprine and atorvastatin being the most common culprits.
- The findings suggest that increased awareness and a proposed diagnostic algorithm may improve the identification and management of drug-induced pancreatitis, highlighting the need for drug assessment when diagnosing AP.
Translational studies benefit from experimental designs where laboratory organisms use human-relevant behaviors. One such behavior is decision-making, however studying complex decision-making in rodents is labor-intensive and typically restricted to two levels of cost/reward. We design a fully automated, inexpensive, high-throughput framework to study decision-making across multiple levels of rewards and costs: the REward-COst in Rodent Decision-making (RECORD) system.
View Article and Find Full Text PDFObjective: To present the baseline clinical and demographic characteristics of CRSwNP patients over the age of 18 enrolled in a Patient Support Program (PSP) prior to biologic treatment.
Methods: Descriptive, cross-sectional study performed in a Colombian CRSwNP asthma PSP sponsored by Sanofi from Aug-2021 to Jul-2022. Data was collected from CRSwNP patients, prior to the start of Dupilumab treatment, who consented to the use of their data.