Publications by authors named "P L Madsen"
Article Synopsis
- mRNA vaccines, initially developed for cancer control, have emerged as crucial tools in fighting infectious diseases, particularly during the COVID-19 pandemic.
- The review explores advancements in mRNA vaccine technology, including personalized vaccines showing promise against tough cancers like pancreatic cancer and melanoma, and considers their potential against difficult tumors like glioblastoma.
- A comprehensive roadmap is presented for using mRNA vaccines to enhance cancer immunotherapy, with a focus on glioblastoma treatments through innovative combinations of RNA science and immunotherapies.
Article Synopsis
- Current prognostic tools for colorectal cancer (CRC) are inadequate, making it essential to find better methods for personalized treatment.* -
- This study investigated the role of circulating tumor DNA (ctDNA) biomarkers in predicting patient outcomes, analyzing samples from CRC patients diagnosed within 24 months.* -
- Results showed that certain methylated ctDNA markers, particularly RARB, SDC2, and WNT5A, independently predicted overall survival, recurrence-free survival, and poor prognosis, suggesting their potential use in personalized treatment strategies.*
Background: Coronary computed tomography angiography (CCTA) is recommended as the first-line diagnostic imaging modality in low-to-intermediate-risk individuals suspected of stable coronary artery disease (CAD). However, CCTA exposes patients to ionizing radiation and potentially nephrotoxic contrast agents. Invasive coronary angiography is the gold-standard investigation to guide coronary revascularisation strategy; however, invasive procedures incur an inherent risk to the patient.
View Article and Find Full Text PDFBackground: The clinical part of this randomized controlled trial concerning phototherapy of neonates with hyperbilirubinemia showed that the recommended blue-green LED light (≈478 nm) was 31% more efficient than standard blue LED light (≈459 nm) measured by the decline in total serum bilirubin. Lumirubin has biologic effects. The aim was to compare the serum bilirubin isomers, efficacy, and biologic effects between the two phototherapy groups.
View Article and Find Full Text PDFPediatric brain cancer is the leading cause of disease-related mortality in children, and many aggressive tumors still lack effective treatment strategies. We characterized aberrant alternative splicing across pediatric brain tumors, identifying pediatric high-grade gliomas (HGGs) among the most heterogeneous. Annotating these events with UniProt, we identified 11,940 splice events in 5,368 genes leading to potential protein function changes.
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