High-Throughput Formation of Pre-Vascularized hiPSC-Derived Hepatobiliary Organoids on a Chip via Nonparenchymal Cell Grafting.

Liver organoids have been increasingly adopted as a critical in vitro model to study liver development and diseases. However, the pre-vascularization of liver organoids without affecting liver parenchymal specification remains a long-lasting challenge, which is essential for their application in regenerative medicine. Here, the large-scale formation of pre-vascularized human hepatobiliary organoids (vhHBOs) is presented without affecting liver epithelial specification via a novel strategy, namely nonparenchymal cell grafting (NCG).

Prevalence and molecular characteristics of colistin-resistant isolates among carbapenem-resistant Klebsiella pneumoniae in Central South China: a multicenter study.

Background: The emergence of colistin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) is a significant public health concern, as colistin has been the last resort for treating such infections. This study aimed to investigate the prevalence and molecular characteristics of colistin-resistant CRKP isolates in Central South China.

Methods: CRKP isolates from twelve hospitals in Central South China were screened for colistin resistance using broth microdilution.

Cellulose nanofibers reinforced carboxylated nitrile butadiene rubber coatings for improved corrosion protection of mild steel.

The development of an efficient coating with comprehensive antimicrobial and anticorrosion properties for metals is crucial. The present study used a one-pot strategy to fabricate a high-performance nanocomposite coating of carboxylated nitrile butadiene rubber/cellulose nanofibers/zinc oxide (XNBR/CNF-ZnO), demonstrating excellent potential for application in the protection against metal corrosion. Eco-friendly CNF-ZnO nanomaterials, prepared using the in-situ generation method, were used as reinforcing fillers, while XNBR was used as the matrix material.

Targeted Mitochondrial Function for Cardiac Fibrosis: an Epigenetic Perspective.

Mitochondria, commonly referred to as "energy factories"of cells, play a crucial role in the function and survival of cardiomyocytes. However, as research on cardiac fibrosis has advanced, mitochondrial dysfunction(including changes in energy metabolism, calcium ion imbalance, increased oxidative stress, and apoptosis)is now recognized as a significant pathophysiological pathway involved in cardiac remodeling and progression, which also negatively affects the function and structure of the heart. In recent years, research focusing on targeting mitochondria has gained significant attention, offering new approaches for treating cardiac fibrosis.

Coordination Equilibrium-Assisted Coprecipitation Synthesis of Atomically Dispersed 3d Metal Catalysts.

As a frontier of heterogeneous catalysis, single-atom catalysts (SACs) have been extensively studied fundamentally. One obstacle that limits the industrial application of SACs is the lack of a synthetic method that can prepare the catalysts on a large scale. Wet-chemistry methods that are conventionally used to prepare nanoparticle-based industrial catalysts might be a solution.