Publications by authors named "P L J DeKoninck"
Background: Physiological-based cord clamping (PBCC) in preterm infants is beneficial for cardiovascular transition at birth and may optimize placental transfusion. Whether PBCC can improve clinical outcomes is unknown. The aim of the Aeration, Breathing, Clamping (ABC3) trial was to test whether PBCC results in improved intact survival in very preterm infants.
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- Infants with congenital diaphragmatic hernia often face serious breathing issues, but a technique called physiologically based cord clamping (PBCC) can help improve blood flow to their lungs when performed before cutting the umbilical cord.
- In a study involving lambs with surgically induced diaphragmatic hernia, PBCC was tested against immediate cord clamping to see its effects on lung function over an 8-hour period following birth.
- Results showed that lambs undergoing PBCC had significantly higher pulmonary blood flow and lower pulmonary vascular resistance compared to those with immediate cord clamping, indicating that PBCC is more beneficial for lung health in this condition.
Article Synopsis
- The study aimed to evaluate the outcomes of fetuses who had open fetal spina bifida surgery in Canada, collecting data on treatment needs and various developmental aspects post-surgery.
- A total of 41 fetuses underwent the procedure from 2017 to 2022, with 24 providing follow-up data at a median age of 46.5 months; results revealed mixed outcomes including a significant need for bladder management and varied motor skills.
- The findings highlighted that while many children displayed typical communication and problem-solving abilities, a majority faced delays in gross motor development, reflecting similar results to previous studies like the MOMs trial.
Objective: To evaluate the diagnostic yield of exome sequencing (ES) in fetuses and neonates with prenatally detected congenital diaphragmatic hernia (CDH) and normal copy number variant (CNV) analysis.
Methods: We conducted a retrospective cohort study of prenatally diagnosed CDH cases seen between 2019 and 2022. All cases who underwent prenatal or postnatal genetic testing were reviewed.
Multicentre, randomised controlled trial of physiological-based cord clamping versus immediate cord clamping in infants with a congenital diaphragmatic hernia (PinC): statistical analysis plan.
Trials
March 2024
Background: Infants born with congenital diaphragmatic hernia (CDH) are at high risk of respiratory insufficiency and pulmonary hypertension. Routine practice includes immediate clamping of the umbilical cord and endotracheal intubation. Experimental animal studies suggest that clamping the umbilical cord guided by physiological changes and after the lungs have been aerated, named physiological-based cord clamping (PBCC), could enhance the fetal-to-neonatal transition in CDH.
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