Publications by authors named "P L Ivanov"
The Putative Antilipogenic Role of NRG4 and ERBB4: First Expression Study on Human Liver Samples.
Front Biosci (Landmark Ed)
December 2024
Background: Epidermal growth factor receptor 4 (ERBB4) and neuregulin 4 (NRG4) have been shown to reduce steatosis and prevent the development of non-alcoholic steatohepatitis in mouse models, but little to nothing is known about their role in non-alcoholic fatty liver disease (NAFLD) in humans. This study is the first to investigate the expression of and mRNAs and their role in lipid metabolism in the livers of individuals with obesity, type 2 diabetes and biopsy-proven NAFLD.
Methods: Liver biospecimens were obtained intraoperatively from 80 individuals.
Article Synopsis
- Guanine-rich nucleic acid sequences can impact biological processes, exhibiting both cytotoxic and cytoprotective effects, though the underlying mechanisms are not fully understood.
- This study focuses on G-rich DNA oligonucleotides that form G-quadruplexes (G4s) and reveals that their biological effects depend on their structure; specifically, only parallel G4s can inhibit eukaryotic translation by interacting with the translation initiation protein EIF4G1.
- This research establishes a direct link between the topology of G4s and their functional outcomes, paving the way for the design of G-rich oligonucleotides for therapeutic applications.
Thyroglobulin is a major autoantigen to which autoimmune response, destroying the thyroid gland in Hashimoto's thyroiditis, is directed. To detect a pathological autoimmune response to thyroglobulin, as well as the successful induction of experimental autoimmune thyroiditis, thyroglobulin carrying thyroiditogenic epitopes is necessary. It is not known which features of thyroglobulin structure determine the presence of thyroiditogenic epitopes and can serve as markers of their presence.
View Article and Find Full Text PDFWe investigate the onset of quantum thermalization in a system governed by the Jahn-Teller Hamiltonian, which describes the interaction between a single spin and two bosonic modes. We find that the Jahn-Teller model exhibits a finite-size quantum phase transition between the normal phase and two types of super-radiant phase when the ratios of spin-level splitting to each of the two bosonic frequencies grow to infinity. We test the prediction of the eigenstate thermalization hypothesis in the Jahn-Teller model.
View Article and Find Full Text PDFArticle Synopsis
- Chronic stress alters cellular reactions by interfering with RNA metabolism, leading to potential contributions to disease, yet this aspect has not been widely studied.
- Stress granules (SGs), which typically form in response to acute stress, do not assemble in cells exposed to chronic, low-dose stress conditions.
- The study found that chronic stress slows down mRNA translation, induces ribosome stalling, and ultimately prevents the formation of SGs during subsequent acute stress scenarios.