Publications by authors named "P L Icely"
Article Synopsis
- The study investigates cellular immunity responses against SARS-CoV-2 among patients in Córdoba, Argentina, during two distinct waves of the pandemic that featured different viral variants and social behavior.
- Findings reveal a disruption in lymphocyte populations, specifically noting an increase in B cells and a decrease in CD3 T cells compared to healthy donors, with a more significant reduction in Tregs among severe cases.
- Results suggest a potential new biomarker, the CD8/CD8 index, for predicting disease progression, as it correlated with increased severity while also showing altered effector cytokine production in T cell populations.
Different cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities.
Front Immunol
February 2023
Article Synopsis
- This study investigates the effects of cytokine storms in COVID-19 patients from Córdoba, Argentina, comparing data from the first two waves of the pandemic to understand links between demographics, comorbidities, and disease outcomes.
- Results showed that patients during the second wave were younger and had fewer comorbidities, with distinct cytokine and chemokine profiles, while pre-existing conditions did not significantly impact cytokine levels.
- The research identified specific inflammatory markers, such as IL-6 and C-reactive protein, that could help predict patient outcomes, particularly differentiating between mortality and recovery during the first wave of infections.
Invasive candidiasis encompassing bloodstream infections and deep-seated candidiasis can become a persistent health problem. These infections are caused by species and have high morbidity and mortality rates. Species distribution, access to diagnosis, treatment and mortality are different around the world.
View Article and Find Full Text PDFVulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) are two forms of a disease caused by spp. β-defensin (BD) is one of the most important families of antimicrobial peptides in the female genital tract and includes molecules that exert essential local functions as antimicrobial and PMN chemoattractant peptides. However, the information on their role during murine and human VVC and RVVC is limited.
View Article and Find Full Text PDFCandidemia is the most frequent invasive mycosis in hospitalized patients worldwide. Fungal infection in central nervous system is a life-threatening complication which aggravates patients' prognosis. This article summarizes relevant aspects on the clinical characteristics of this pathology, mechanisms of fungus invasion, local immune response to Candida albicans and the impact of genetic defects on innate immune receptors that increase susceptibility to the acquisition of this form of mycosis.
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