Publications by authors named "P L Hedley"
Background: Leptin is a hormone which is secreted by the adipocytes. In the circulation, leptin levels are directly proportional to the body fat percentage. Studies have shown that higher leptin levels are associated with an increased risk of hypertension after adjusting for body mass index (BMI).
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- Understanding the risk profile of obstetric complications in pregnancies with fetal major congenital heart defects (MCHDs) is essential for effective counseling and care.
- This cohort study analyzed data from over 534,000 pregnancies in Denmark between 2008 and 2018, focusing on the link between fetal MCHDs and adverse obstetric outcomes like preeclampsia and preterm birth.
- Results showed that pregnancies with fetal MCHDs had a significantly higher rate of adverse outcomes (22.8%) compared to those without MCHDs (9.0%), highlighting the increased risks associated with these conditions.
Article Synopsis
- The study investigates the prevalence of omphalocele, a serious congenital defect, in a large cohort of live births in Denmark from 1997-2021.
- More than half of the infants with omphalocele were found to have additional major malformations, indicating a significant risk for complications.
- These findings emphasize the need to consider the long-term healthcare requirements for infants with omphalocele and associated syndromes.
Article Synopsis
- - The study examined trends in gastroschisis prevalence among Danish infants over 28 years, revealing a significant annual increase of 2.8%, reaching a prevalence of 1.64 per 10,000 live births.
- - The majority of infants (77.7%) presented with isolated gastroschisis, while a smaller percentage (21.9%) had co-occurring malformations, particularly cardiovascular and intestinal issues.
- - Overall, while gastroschisis cases have risen, the occurrence of associated malformations has not shown a similar increase; future research will focus on healthcare patterns and long-term outcomes for these infants.
Winter dormancy is a key process in the phenology of temperate perennials. Climate change is severely impacting its course leading to economic losses in agriculture. A better understanding of the underlying mechanisms, as well as the genetic basis of the different responses, is necessary for the development of climate-resilient cultivars.
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