Construction of the Bicyclic Carbon Framework of Euphosalicin.

Our studies toward the total synthesis of the natural product euphosalicin () are presented. Different approaches targeting key intermediates are described, the synthesis of which includes findings on asymmetric dihydroxylations and ring-closing enyne metatheses (RCEYM). Their connection allowed the isolation of highly advanced precursors for studies on macrocyclizations.

! Europium-catalyzed [3,3] and [5,5] rearrangements of aryl-pentadienyl ethers.

A general protocol for the europium-catalyzed rearrangement of aryl-pentadienyl-ethers is described. The mode of rearrangement and product formation in this reaction was solely determined by the aryl substituent to the phenol. If the -position is occupied by a substituent, the substrate undergoes a [3,3] rearrangement to the -position to form a prochiral branched diene.

Systematic Retesting for : The Potential Overestimation of Suppressive Conditions.

Background And Aims: In contrast to guideline recommendations, endoscopic testing for is frequently performed under suppressive conditions, e.g., intake of proton-pump inhibitors (PPI), preceded antibiotic treatment, or recent gastrointestinal bleeding.

Surface-active ionic liquids in micellar catalysis: impact of anion selection on reaction rates in nucleophilic substitutions.

A series of surface-active ionic liquids based on the 1-dodecyl-3-methylimidazolium cation and different anions such as halides and alkylsulfates was synthesized. The aggregation behavior of these ionic liquids in water was characterized by surface tension, conductivity measurements and UV-Vis spectroscopy in order to determine the critical micelle concentration (CMC) and to provide aggregation parameters. The determination of surface activity and aggregation properties of amphiphilic ionic liquids was accompanied by SAXS studies on selected surface-active ionic liquids.