AI-powered prostate cancer detection: a multi-centre, multi-scanner validation study.

Objectives: Multi-centre, multi-vendor validation of artificial intelligence (AI) software to detect clinically significant prostate cancer (PCa) using multiparametric magnetic resonance imaging (MRI) is lacking. We compared a new AI solution, validated on a separate dataset from different UK hospitals, to the original multidisciplinary team (MDT)-supported radiologist's interpretations.

Materials And Methods: A Conformité Européenne (CE)-marked deep-learning (DL) computer-aided detection (CAD) medical device (Pi) was trained to detect Gleason Grade Group (GG) ≥ 2 cancer using retrospective data from the PROSTATEx dataset and five UK hospitals (793 patients).

High-Efficiency Y6 Homojunction Organic Solar Cells Enabled by a Secondary Hole Transport Layer.

Y6 homojunction solar cells are prepared using the exciton/electron-blocking material poly[9,9-di-n-octylfluorene-alt-N-(4-sec-butylphenyl)diphenylamine] (TFB) as a secondary hole transport layer material in conjunction with PEDOT:PSS. Using this device architecture, a maximum power conversion efficiency (PCE) of 2.57% is achieved, which is the highest reported thus far for a solution-processed small molecule homojunction organic photovoltaic (OPV) device.

Enhanced Efficiency and Stability in Blade-Coated Perovskite Solar Cells through Using 2,3,4,5,6-Pentafluorophenylethylammonium Halide Additives.

The power conversion efficiency (PCE) of perovskite solar cells is sensitive to their method of fabrication as well as the combination of materials in the perovskite layer. Air knife-assisted blade coating enables good quality perovskite films to be formed but the device efficiencies still tend to lag behind those fabricated using spin-coated perovskite layers. Herein we report the use of three 2,3,4,5,6-pentafluorophenylethylammonium halides (FEAX, where X = I, Br or Cl) as additives in nitrogen knife-assisted blade-coated methylammonium lead iodide (MAPbI) perovskite solar cells.

Effect of Silyl Ether Bulk on Excited-State Intramolecular Proton Transfer-Based Sensing of Extant Hydrogen Fluoride for G-Series Nerve Agent Detection.

Luminescence-based sensing provides a method for the rapid detection of nerve agents. Previous approaches have generally focused on sensing materials containing a nucleophilic group that can react with the electrophilic phosphorus atom found in nerve agents. Herein we report an alternative approach for the detection of phosphonofluoridate-based G-series nerve agents that utilizes the fact they contain hydrogen fluoride.

Interplay between the Glass Transition Temperature, Analyte Diffusion, and Fluorescence Quenching for Detection of Nitro-Group Containing Explosives Using Organic Semiconducting Films.

Efficient detection of chemical analytes using fluorescence-based sensors necessitates an in-depth understanding of the physical interaction between the analyte molecules and the sensor films. This study explores the interplay between the thermal properties of a series of triphenylamine-centered fluorescent dendrimers with different glass transition temperatures () for detecting nitroaromatic explosives. When exposed to 4-nitrotoluene (pNT) vapors, biphasic diffusion kinetics were observed for all the dendrimers, corresponding to Super Case II kinetics, suggesting rapid film swelling during initial analyte uptake.