Publications by authors named "P L Bitolog"
Performance of visual inspection, partial genotyping, and their combination for the triage of women living with HIV who are screen positive for human papillomavirus: Results from the AIMA-CC ANRS 12375 multicentric screening study.
Int J Cancer
February 2025
Article Synopsis
- - The WHO recommends HPV testing for cervical cancer screening due to its high sensitivity, but further triage is needed to identify women with high-grade lesions (CIN2+) who need treatment.
- - The ANRS-12375 study evaluated various triage methods like visual inspection (VIA) and different genotyping options in Côte d'Ivoire, Burkina Faso, and Cambodia to detect CIN2+ lesions among women living with HIV.
- - Results showed that VIA and extended genotyping had high sensitivity (89%), with VIA also exhibiting the best specificity among the tests, making them effective options for identifying women who require treatment for CIN2+.
Article Synopsis
- - The study addresses the challenge of distinguishing metastatic cervical cancer from new primary tumors in patients with a history of cervical cancer by utilizing HPV molecular genotyping tests.
- - Researchers analyzed cases from 2010 to 2020 involving patients with cervical cancer and new lesions, employing a specific PCR method to detect high-risk HPV DNA in those lesions.
- - The findings showed that in most cases, the presence of HPV DNA confirmed cervical cancer metastasis, while one case revealed no HPV, indicating a new primary lung cancer, thus demonstrating the potential efficacy of molecular genotyping in diagnosis.
Purpose: Adrenal ectopy is a rare condition, caused by abnormal embryological development of the adrenal glands and testis. This anomaly is asymptomatic and is generally diagnosed in childhood. Most cases of adrenal ectopy of the groin region have been found incidentally during surgery.
View Article and Find Full Text PDFThe aqueous extract from the leaves of Ocimum suave was evaluated for acute and sub chronic toxicity and teratogenic effects. Swiss mice were administered single oral doses of 2000, 4000, 6000 and 8000 mg/kg and monitored for death and body weight gained for 7 days (acute toxicity). In sub-acute toxicity, experimental rats, received daily doses of 250, 500 and 1000 mg/kg for 42 consecutive days and the toxic effects were assessed using biochemical and haematological data and histology of vital organs.
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