Publications by authors named "P L Bernardo"
Objective: To describe the treatment outcomes of patients who underwent Percutaneous Transluminal Angioplasty (PTA) for Central Vein Occlusive Disease (CVOD) in end-stage kidney disease and determine the association between patient profile and treatment outcomes.
Methods: A single-institution, retrospective review of patients aged 18 and above with end-stage kidney disease who underwent PTA for CVOD in the University of the Philippines - Philippine General Hospital (UP-PGH) from January 1, 2013, to December 31, 2022, was performed. These patients' demographic and clinical profiles were evaluated using means, frequencies, and percentages.
An enteroatmospheric fistula (EAF) is one of the most feared complications of damage control laparotomy. Its management is highly challenging, often requiring multiple surgeries and prolonged hospitalization. It is a serious condition, and despite significant improvements in mortality rates due to advancements in intensive care, the rate remains substantial.
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- The World Health Organization aims to reduce salt intake by 30% by 2025, prompting this study to explore the effects of replacing 33% of NaCl with KCl and microencapsulated spices in a dry-cured meat sausage.
- The formulations tested (Control, F1, F2, F3) maintained microbial safety, showing no growth of harmful bacteria while lactic acid bacteria remained stable.
- Consumer preference indicated that F1, with the adjusted salt levels, was favored as the ideal saltiness for potential market launch, confirming that significant NaCl replacement can be done without compromising taste or safety.
Article Synopsis
- - The study focuses on analyzing tuberculosis incidence in the 399 municipalities of Paraná, Brazil, between 2018 and 2022, using ecological methods and various statistical models to identify patterns and factors influencing the disease.
- - Findings indicate that high-risk areas for tuberculosis are primarily located in the coastal/port, north, and northeast regions of Paraná, with factors such as municipal development index, environmental sanitation issues, and income inequality positively correlating with higher incidence rates.
- - The research highlights a paradox where tuberculosis clusters exist in regions with higher development indices but significant socioeconomic disparities, suggesting that income inequality contributes to ongoing tuberculosis challenges even in relatively developed areas.
Trofinetide is a first-in-class pharmacological treatment proposed for patients with Rett Syndrome. It is a long half-life derivative of glycine-proline-glutamate, the tripeptide normally excided from Insulin-like Growth Factor 1 upon degradation. Due to containing glutamate and glycine in its structure, trofinetide is thought to act through NMDA receptor modulation, thus providing a normalization of neuronal activity and survival.
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