Publications by authors named "P Kwok"
Objectives: Methylene blue exerts its vasopressor properties by inhibiting nitric oxide-mediated vasodilation. Recent studies have advocated the use of methylene blue as a rescue therapy for patients with septic shock. The primary aim was to investigate the effect of methylene blue on the mean arterial pressure among adult patients with septic shock.
View Article and Find Full Text PDFBackground: The use of probiotic bacteria to improve lung health has been gaining interest. Although the oral delivery of probiotics and their effects are well documented, there is currently limited knowledge on the respiratory delivery of probiotics.
Objectives: This study aimed to investigate whether nebulisation is suitable for delivering GG (LGG) into the lungs for the potential treatment of bacterial pulmonary infections.
Introduction: The rising prevalence of difficult-to-treat, deep-seated invasive fungal diseases (IFD) has led to high mortality. Currently available antifungal treatments, administered predominantly orally or intravenously, may not sufficiently penetrate certain body sites, and/or are associated with systemic toxicity. Little is known about how to position alternative administration approaches such as inhalational and direct drug delivery routes.
View Article and Find Full Text PDFArticle Synopsis
- - A 5-year-old girl with severe hemophilia B started having frequent muscle and joint bleeds at 19 months old.
- - Genetic testing identified a mutation in the factor IX gene, as well as a large deletion in the Xq28 region, which is crucial for her condition.
- - These findings not only clarify the severity of her hemophilia but also assist in family planning discussions for her family.
Article Synopsis
- * It found that using magnesium stearate improved aerosol performance and that the shape and size of the particles varied based on the type of inhaler used, with low-resistant inhalers resulting in higher throat deposition.
- * The optimal formulation was determined to be CBD powder with 5% magnesium stearate using a high-resistance inhaler, which showed promising results with the best fine particle fraction and minimal throat deposition, indicating potential for future in vivo testing.