Publications by authors named "P Kvamme"
Background: Mechanical thrombectomy (MT) has become standard for large vessel occlusions, but rates of complete recanalization are suboptimal. Previous reports correlated radiographic signs with clot composition and a better response to specific techniques. Therefore, understanding clot composition may allow improved outcomes.
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- The study examined the relationship between platelet (CD42b) and von Willebrand factor (vWF) levels in emboli from acute ischemic stroke patients to understand their impact on stroke causes and procedures.
- CD42b/vWF expression was evaluated in a total of 288 emboli samples, revealing that higher vWF levels were linked to certain stroke causes while platelet levels correlated with treatment success.
- The findings indicate that the distribution patterns of CD42b and vWF in clots are associated with the etiology of strokes and outcomes from thrombolysis, particularly showing variations based on the type of embolism.
Background And Purpose: Given recent evidence suggesting the clot composition may be associated with revascularization outcomes and stroke etiology, clot composition research has been a topic of growing interest. It is currently unclear what effect, if any, pre-thrombectomy thrombolysis has on clot composition. Understanding this association is important as it is a potential confounding variable in clot composition research.
View Article and Find Full Text PDFBackground: Compositional and structural features of retrieved clots by thrombectomy can provide insight into improving the endovascular treatment of ischemic stroke. Currently, histological analysis is limited to quantification of compositions and qualitative description of the clot structure. We hypothesized that heterogeneous clots would be prone to poorer recanalization rates and performed a quantitative analysis to test this hypothesis.
View Article and Find Full Text PDFBackground: Several animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following MT are difficult to determine.
Objective: To investigate the occurrence of VWI during MT by histological and immunohistochemical evaluation of AIS clots.