Publications by authors named "P Kurre"
Hematopoietic dysfunction has been associated with a reduction in the number of active precursors. However, precursor quantification at homeostasis and under diseased conditions is constrained by the scarcity of available methods. To address this issue, we optimized a method for quantifying a wide range of hematopoietic precursors.
View Article and Find Full Text PDFFanconi anemia (FA) is generally classified as a DNA repair disorder, conferring a genetic predisposition to cancer and prominent bone marrow failure (BMF) in early childhood. Corroborative human and murine studies point to a fetal origin of hematopoietic stem cell (HSC) attrition under replicative stress. Along with intriguing recent insights into non-canonical roles and domain-specific functions of FA proteins, these studies have raised the possibility of a DNA repair-independent BMF etiology.
View Article and Find Full Text PDFCross-talk between hematopoietic stem and progenitor cells (HSPCs) and bone marrow (BM) cells is critical for homing and sustained engraftment after transplantation. In particular, molecular and physical adaptation of sinusoidal endothelial cells (ECs) promote HSPC BM occupancy; however, signals that govern these events are not well understood. Extracellular vesicles (EVs) are mediators of cell-cell communication crucial in shaping tissue microenvironments.
View Article and Find Full Text PDFLifelong hematopoiesis is sustained by crosstalk between hematopoietic stem and progenitor cells (HSPCs) and specialized bone marrow niches. Acute myeloid leukemia (AML) upends that balance, as leukemic blasts secrete factors that remodel the bone marrow into a self-reinforcing leukemic niche. The inflammatory secretome behind this compartmental adaptation accounts for a progressive decline in hematopoietic function that leads to diagnosis and persists through early treatment.
View Article and Find Full Text PDFArticle Synopsis
- Hematopoietic dysfunction leads to fewer active precursors, but accurately measuring these precursors has been difficult due to limited methods available.
- The researchers created an optimized method to quantify a variety of hematopoietic precursors using a stable labeling technique based on a binomial distribution model, validated in mice.
- Their study found that a significant number of precursors arise during the transition from fetal to adult stages and highlighted repopulation deficits in a Fanconi Anemia mouse model, reinforcing the concept that hematopoiesis is highly diverse.