Publications by authors named "P Krimpenfort"
Article Synopsis
- * In humans, TAGs are primarily synthesized by diacylglycerol O-acyltransferases (DGAT1 and DGAT2), but researchers have discovered an alternative TAG-synthesizing system involving a protein called DIESL and its regulator TMX1.
- * DIESL functions as an independent TAG synthase and is essential for energy balance, particularly during nutrient shortages, with its deficiency shown to negatively impact growth and energy management in mice.
Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease. Multiple factors can contribute to ageing-associated inflammation; however, the molecular pathways that transduce aberrant inflammatory signalling and their impact in natural ageing remain unclear. Here we show that the cGAS-STING signalling pathway, which mediates immune sensing of DNA, is a critical driver of chronic inflammation and functional decline during ageing.
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- Liver transplantation is the best way to treat patients with severe liver disease, but problems can happen after the surgery, like damage to bile ducts that can lead to losing the new liver.
- Scientists studied how keeping livers cold before surgery affects liver cells and found that cold storage can hurt the cells and stop them from healing properly.
- They discovered a specific receptor in the liver cells that can help with cell growth and lessen damage, and using certain treatments before and during liver storage can help keep the liver healthier for the transplant.
The experimental need to engineer the genome both in time and space, has led to the development of several photoactivatable Cre recombinase systems. However, the combination of inefficient and non-intentional background recombination has prevented thus far the wide application of these systems in biological and biomedical research. Here, we engineer an optimized photoactivatable Cre recombinase system that we refer to as doxycycline- and light-inducible Cre recombinase (DiLiCre).
View Article and Find Full Text PDFProtein synthesis generally starts with a methionine that is removed during translation. However, cytoplasmic actin defies this rule because its synthesis involves noncanonical excision of the acetylated methionine by an unidentified enzyme after translation. Here, we identified C19orf54, named ACTMAP (actin maturation protease), as this enzyme.
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