Publications by authors named "P Kreuzer"
Background: Pneumocystis jirovecii pneumonia (PCP) is a serious opportunistic infection in people living with HIV (PWH) who have low CD4 counts. Despite its side effects, trimethoprim-sulfamethoxazole (TMP-SMX) is currently considered the primary treatment for PCP.
Objectives: To compare the efficacy (treatment-failure and mortality) and tolerability (treatment change) of PCP treatment-regimens with a frequentist network meta-analysis (NMA).
Article Synopsis
- Invasive pulmonary aspergillosis (IPA) is increasingly affecting critically ill ICU patients who lack traditional risk factors, complicating diagnosis due to histological evidence challenges.
- A study analyzed 202 patients across nine centers, comparing existing classification criteria (EORTC-MSG, FUNDICU, Asp-ICU) for diagnosing IPA and their effectiveness in identifying cases confirmed by histology.
- Findings revealed that EORTC-MSG was highly effective in patients with known risk factors, while the FUNDICU criteria's accuracy improved when including factors like ARDS and post-cardiac surgery complications, enhancing its predictive performance.
Objectives: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a cytokine-driven inflammatory syndrome that is associated with substantial morbidity and mortality and frequently leads to ICU admission. Overall survival in adults with sHLH remains poor, especially in those requiring intensive care. Classical chemotherapeutic treatment exhibits myelosuppression and toxicity.
View Article and Find Full Text PDFPivotal outcome trials targeting heart failure with preserved (HFpEF) and mildly-reduced ejection fraction (HFmrEF) may have excluded patients at highest risk of poor outcomes. We aimed to assess eligibility for HFpEF/HFmrEF outcome trials in an unselected heart failure cohort and its association with all-cause mortality. Among 32.
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