"CodonWizard" - An intuitive software tool with graphical user interface for customizable codon optimization in protein expression efforts.

Optimization of coding sequences to maximize protein expression yield is often outsourced to external service providers during commercial gene synthesis and thus unfortunately remains a black box for many researchers. The presented software program "CodonWizard" offers scientists a powerful but easy-to-use tool for customizable codon optimization: The intuitive graphical user interface empowers even scientists inexperienced in the art to straightforward design, modify, test and save complex codon optimization strategies and to publicly share successful otimization strategies among the scientific community. "Codon Wizard" provides highly flexible features for sequence analysis and completely customizable modification/optimization of codon usage of any given input sequence data (DNA/RNA/peptide) using freely combinable algorithms, allowing for implementation of contemporary, well-established optimization strategies as well as novel, proprietary ones alike.

Automatic multimodal 2D/3D breast image registration using biomechanical FEM models and intensity-based optimization.

Due to their different physical origin, X-ray mammography and Magnetic Resonance Imaging (MRI) provide complementary diagnostic information. However, the correlation of their images is challenging due to differences in dimensionality, patient positioning and compression state of the breast. Our automated registration takes over part of the correlation task.

The impact of the demographics of aging and the edentulous condition on dental care services.

Over the next 20 years, the number of people aged 65 years and older is expected to increase substantially in both Canada and the United States. Moreover, advances in dental treatment are resulting in reduced levels of the edentulous condition, such that there will be more people in need of various dental services. The purpose of this study was to determine what effect the increase in the overall population of the United States and Canada, and specific cohorts such as the senior citizen population, would have on the decrease in the levels of the edentulous condition.