Saturation transfer (CEST and MT) MRI for characterization of U-87 MG glioma in the rat.

The focus of this work was to identify the optimal magnetic resonance imaging (MRI) contrast between orthotopic U-87 MG tumours and normal appearing brain with the eventual goal of treatment response monitoring. U-87 MG human glioblastoma cells were injected into the brain of RNU nude rats (n = 9). The rats were imaged at 7 T at three timepoints for all animals: 3-5, 7-9, and 11-13 days after implantation.

The Impact of 1030 nm fs-Pulsed Laser on Enhanced Rayleigh Scattering in Optical Fibers.

This article presents a comprehensive study on the impact of irradiation optical fiber cores with a femtosecond-pulsed laser, operating at a wavelength of 1030 nm, on the signal amplitude in Rayleigh scattering-based optical frequency domain reflectometry (OFDR). The experimental study involves two fibers with significantly different levels of germanium doping: the standard single-mode fiber (SMF-28) and the ultra-high numerical aperture fiber (UHNA7). The research findings reveal distinct characteristics of reflected and scattered light amplitudes as a function of pulse energy.

Scattering correction for samples with cylindrical domains measured with polarized infrared spectroscopy.

Scattering artifacts are one of the most common effects distorting transmission spectra in Fourier-Transform Infrared spectroscopy. Their increased impact, strongly diminishing the quantitative and qualitative power of IR spectroscopy, is especially observed for structures with a size comparable to the radiation wavelength. To tackle this problem, a wide range of preprocessing techniques based on the Extended Multiplicative Scattering Correction method was developed, using physical properties to remove scattering presence in the spectra.

Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach.

Infrared (IR) based histopathology offers a new paradigm in looking at tissues and can provide a complimentary information source for more classical histopathology, which makes it a noteworthy tool given possible clinical application. This study aims to build a robust, pixel level machine learning model for pancreatic cancer detection using IR imaging. In this article, we report a pancreatic cancer classification model based on data from over 600 biopsies (coming from 250 patients) imaged with IR diffraction-limited spatial resolution.

Relationship between GABA-Ergic System and the Expression of Mephedrone-Induced Reward in Rats-Behavioral, Chromatographic and In Vivo Imaging Study.

Mephedrone is a psychoactive drug that increases dopamine, serotonin and noradrenaline levels in the central nervous system via interaction with transporters or monoamines. The aim of the presented study was to assess the role of the GABA-ergic system in the expression of mephedrone-induced reward. For this purpose, we conducted (a) a behavioral evaluation of the impact of baclofen (a GABA receptors agonist) and GS39783 (a positive allosteric modulator of GABA receptors) on the expression of mephedrone-induced conditioned place preference (CPP) in rats, (b) an ex vivo chromatographic determination of the GABA level in the hippocampi of rats subchronically treated with mephedrone and (c) an in vivo evaluation of GABA hippocampal concentration in rats subchronically administered with mephedrone using magnetic resonance spectroscopy (MRS).