Publications by authors named "P Korner"
Messenger RNA (mRNA) translation is a tightly controlled process frequently deregulated in cancer. Key to this deregulation are transfer RNAs (tRNAs), whose expression, processing and post-transcriptional modifications are often altered in cancer to support cellular transformation. In conditions of limiting levels of amino acids, this deregulated control of protein synthesis leads to aberrant protein production in the form of ribosomal frameshifting or misincorporation of non-cognate amino acids.
View Article and Find Full Text PDFThe focus of this work is to enhance state-of-the-art Machine Learning (ML) models that can predict the aerobic biodegradability of organic chemicals through a data-centric approach. To do that, an already existing dataset that was previously used to train ML models was analyzed for mismatching chemical identifiers and data leakage between test and training set and the detected errors were corrected. Chemicals with high variance between study results were removed and an XGBoost was trained on the dataset.
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- Transfer RNA (tRNA) dynamics play a significant role in cancer by influencing how messenger RNA (mRNA) translates into proteins, specifically through aminoacyl-tRNA synthetases that can either encourage or inhibit tumor growth.
- Research indicates that valine aminoacyl-tRNA synthetase (VARS) is crucial for the changes in protein translation related to resistance against MAPK therapy in melanoma patients, as there is an increased use of valine in their proteomes.
- Additionally, reducing VARS levels can make MAPK-resistant melanoma cells more sensitive to treatment, as VARS is linked to the translation of key mRNAs that support cell survival via fatty acid oxidation.
Article Synopsis
- Human cells can trigger a form of programmed cell death (apoptosis) when faced with DNA damage, primarily through the activation of the p53 protein.
- Interestingly, even cells without p53 can still undergo apoptosis, which seems to be linked to issues with protein translation, specifically ribosomes stalling on rare codons and reduced translation initiation.
- A genetic study revealed that the tRNAse SLFN11 and the kinase GCN2 are crucial for this stalling and subsequent stress signaling, which leads to apoptosis, offering insights into chemotherapy resistance in certain tumors where SLFN11 is often inactive.
This pilot study investigated whether sonic-powered application of a bulk-fill resin-based composite (RBC) in Class-II or endodontic access cavities reduces void formation. The crowns and roots of 60 bovine teeth with Class-II cavities (C) and endodontic access cavities (E) respectively, were assigned to ten groups (C1-C5, E1-E5). Cavities were filled with RBC (SDR flow + , one increment) using different application techniques: no adaptation (C1 + E1), spreading of RBC on the cavity surfaces with a dental explorer tip (C2 + E2), low (C3 + E3) or high frequency (C4 + E4) direct activation by inserting a sonic-powered tip into RBC and high frequency indirect activation with an ultrasonic insertion tip (C5 + E5).
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