[Facial skeleton traumas in farmers in east-central region of Poland (part I)].

On the base of medical documentation, we presented epidemiological analysis of 215 patients treated for traumas of facial skeleton, which occurred during agricultural tasks. It was concluded that the injuries mentioned above occurred more frequently in males at the age between 18-40. The traumas in this group occurred mainly during use of jig saw or other tools and machinery used in agriculture.

[Symptoms of temporomandibular joint dysfunction in patients treated for the condylar fractures].

124 patients at the age of 7 to 70 years with condylar fractures were treated in the Department of Dental and Maxillo-Facial Surgery in the years 1992-96. The authors carried out control clinical examinations and the radiographic investigations in 42 patients treated conservatively. Late results of treatment were assessed after 5 since post fracture.

Pharmacokinetics of mexiletine and its metabolites, hydroxymethylmexiletine and p-hydroxymexiletine, after single oral administration in healthy subjects.

Pharmacokinetics of mexiletine and its major metabolites, p-hydroxymexiletine and hydroxymethylmexiletine, were studied in 10 healthy subjects after administration of a single oral 400 mg dose. Mexiletine was extensively metabolized to hydroxymethylmexiletine and less to p-hydroxymexiletine. Mean metabolic ratio (Rm) was 0.

[Evaluation of the relative biological availability of amiodarone Polfa preparation after extravascular administration of a single dose].

Relative bioavailability of amiodarone was studied in 10 healthy volunteers after its 600 mg single dose administration. Mean values of individual maximal concentrations and time for reaching them did not significantly differ and were respectively 0.828 +/- 0.