Publications by authors named "P Kokotis"
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders, manifesting multiple clinical autoimmune inflammatory phenomena, including rarely peripheral neuropathy. Twenty-four patients diagnosed with MDS and 29 healthy subjects were enrolled in this prospective study in a 5-year period. Every subject was assessed by symptoms questionnaire and clinical neurological examination followed by nerve conduction studies, quantitative sensory testing and skin biopsy.
View Article and Find Full Text PDFIntroduction Peripheral neuropathy is a well-known manifestation of alcohol overconsumption, but neurophysiological confirmation of peripheral nerve damage is costly and sometimes involves invasive procedures. The aim of this study was to investigate the ability of commonly used clinical scales to detect the presence of neuropathy in patients with alcohol use disorder (AUD). Methods Data were collected retrospectively on 116 patients diagnosed with AUD and treated voluntarily in a detoxification special unit.
View Article and Find Full Text PDFArticle Synopsis
- Autoimmune nodopathies are a new type of immune-mediated peripheral neuropathies linked to autoantibodies targeting specific proteins, with evidence showing an increased risk for these conditions in diabetes mellitus (DM) patients.* -
- A systematic review identified 114 patients with autoimmune nodopathies, revealing that the prevalence of DM among them varied from 10.5% to 60%, predominantly with paranodal antibodies like CNTN1.* -
- Key distinctive clinical features of autoimmune nodopathies compared to diabetic peripheral neuropathy included severe ataxia, specific neurophysiological patterns, and abnormal findings in cerebrospinal fluid analysis, while DM patients showed limited response to standard treatments.*
Background/aim: Oxaliplatin, a platinum-based chemotherapy used in the treatment of colorectal cancer, induces acute neurotoxicity following infusion. The aim of this study was to establish whether alterations in axonal excitability develop progressively with higher cumulative doses and whether there is a recovery in motor axons after each cycle of treatment.
Patients And Methods: Twenty consecutive patients with a colorectal cancer diagnosis, referred from the Oncology Department of Aretaieion Hospital of Athens, were enrolled in this study between October 2018 and May 2019.