Publications by authors named "P Kluge"
Article Synopsis
- - Coagulation factor XII (FXII) is linked to thrombosis and inflammation and is found in increased levels in diabetes and diabetic kidney disease (DKD), but its specific role in DKD was unclear until now.
- - The study reveals that FXII is present in kidney tubular cells, correlating with kidney dysfunction in DKD patients; mice lacking FXII showed protection against kidney damage from high blood sugar.
- - FXII promotes cell damage through a signaling pathway involving uPAR and integrin β1, leading to oxidative stress and cell aging; blocking these pathways may provide new diagnostic and treatment options for DKD and similar diseases.
Background And Objectives: This work provides an overview of the incentives used for plasma donation in Europe and beyond. The overview can provide new ideas to blood establishments.
Materials And Methods: We conducted a systematic online search of incentives used and asked national experts to validate the data across all European Union countries as well as other European and non-European countries.
Article Synopsis
- The study investigates the role of Y-box binding protein 1 (YBX1) in kidney function, particularly in podocytes, and finds that its absence leads to increased albuminuria and varying levels of glomerular and tubular damage in mice.* -
- YBX1 is shown to inhibit the activation of the NLRP3 inflammasome and reduce inflammatory responses in tubular cells by interacting with Toll-like receptor 4 (TLR4).* -
- The research concludes that YBX1 is secreted from podocytes and plays a protective role against tubular inflammation, highlighting its importance in the crosstalk between glomerular and tubular compartments of the kidney.*
Effect of Inoculum Microbial Diversity in Ex Situ Biomethanation of Hydrogen.
Bioengineering (Basel)
November 2022
The effects of the inoculum origin, temperature or operational changes on ex situ biomethanation by complex microbial communities have been investigated; however, it remains unclear how the diversity of the inoculum influences the process and its stability. We explored the effect of microbial diversity of four inocula (coded as PF, WW, S37 and Nrich) on methane production, process stability and the formation of volatile fatty acids as by-products. The highest methane amounts produced were 3.
View Article and Find Full Text PDFSepsis is an exaggerated immune response upon infection with lipopolysaccharide (LPS) as the main causative agent. LPS-induced activation and apoptosis of endothelial cells (EC) can lead to organ dysfunction and finally organ failure. We previously demonstrated that the first twenty amino acids of the Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) are sufficient to inhibit EC apoptosis.
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