Publications by authors named "P Kiely"
Early approval mechanisms, such as conditional approval in the EU, have been used extensively to provide timely access to therapeutic innovations to cancer patients with unmet medical needs. While based on promising early evidence, such approvals are challenging from many perspectives due to the lack of comprehensive data. The limitation typically relates to data that demonstrates clinical benefit via early endpoints and is only acceptable when the early evidence is particularly convincing to assume that the benefits of early access are greater than the potential harms.
View Article and Find Full Text PDFArticle Synopsis
- Angular deformity in the lower limbs can lead to pain, mobility issues, and joint damage, with guided growth now favored over previous treatments for young patients.
- A review of data from a pediatric center from 2007 to 2023 found that out of 282 treated knees, 19.5% experienced treatment failure, particularly in cases involving trauma, infection, tumors, and certain genetic disorders.
- Overall, guided growth achieved an 80.5% success rate, especially effective for idiopathic cases, and continues to be recommended for managing angular deformities.
The Entry-level Competency Standards for Optometry in Australia identify the required knowledge, skills and attributes for an optometrist to practise safely and competently. The 2022 competencies are the sixth generation of entry-level competency standards. To ensure the standards reflect contemporary practice and the expectations placed on optometrists, a full revision of the standards was commenced in late 2019.
View Article and Find Full Text PDFArticle Synopsis
- Pain management in rheumatoid arthritis (RA) remains a significant issue, with many patients still experiencing pain despite treatment with DMARDs and biologics; this study aimed to evaluate the feasibility of comprehensive pain assessments in RA patients on these treatments.* -
- Conducted as an open-label, randomized trial, the study found that while participant recruitment was lower than expected—mostly due to COVID-19—pain assessments were practical and showed improvements in pain scores over 12 months.* -
- Feedback indicated that some pain assessment questionnaires were too long and repetitive, but the overall study met its goals, demonstrating the potential for further research on pain management strategies in RA.*
Article Synopsis
- Nucleic acid-amplification testing (NAT) is a method used to check blood donations for harmful viruses to keep people safe.
- In 2019, a global survey showed that countries mostly followed government rules for testing blood for viruses like HIV and hepatitis.
- The results indicated a trend towards using individual samples for testing instead of larger pools to improve safety in blood donations.