Publications by authors named "P Khamrin"
The BioFire FilmArray® Gastrointestinal (GI) Panel, a widely used diagnostic tool, is designed to detect the genetic material of 22 common pathogens responsible for gastroenteritis, including viruses, bacteria, and parasites. It can detect human adenovirus (HAdV) species F, particularly serotypes F40 and F41, which are the major causes of diarrhea and mortality in children. However, its potential shortcomings in detecting other HAdV species limit its effectiveness in broader HAdV detection in clinical settings and outbreak investigations.
View Article and Find Full Text PDFBackground: Viral gastroenteritis is a significant global health concern. An effective, rapid, and easy-to-use diagnostic tool is essential for screening causative viruses.
Methods: Forty-eight samples, known to be infected with one of the following viruses: norovirus, group A rotavirus, astrovirus, adenovirus, and sapovirus determined by reverse transcription-PCR and nucleotide sequencing, were evaluated by the Fast Track Diagnostics (FTD) viral gastroenteritis assay.
Article Synopsis
- A study analyzed 1,625 stool samples from children with diarrhea in Japan over four years (2018-2022) to detect human astroviruses (HAstVs) and other diarrheal viruses, finding HAstV in 8.6% of samples.
- The prevalence of HAstVs varied by year, with a notable increase to 20.1% in 2021-2022, and a significant infection rate was observed in children aged 1-3 years.
- The study identified multiple HAstV genotypes, including outbreaks of HAstV1 and MLB2 during the COVID-19 pandemic, and noted for the first time a mixed infection of HAstV1 and MLB1.
Coxsackievirus A2 (CVA2), a member of enterovirus A species (EV-A), is associated with diverse human diseases and occasionally causes acute gastroenteritis (AGE). In Thailand, CVA2 emerged as the predominant genotype in 2019. The increasing incidence of CVA2, coupled with the limited availability of full-length genomes, highlights the need for more complete genome sequence analysis to facilitate molecular epidemiology study.
View Article and Find Full Text PDFArticle Synopsis
- Viral enteric infections, caused by norovirus, rotavirus A, and human adenovirus, significantly impact the gastrointestinal system, highlighting the need for rapid diagnostic tools like the immunochromatographic (IC) test.
- The IP-Triple I IC test kit was evaluated against known positive stool specimens and showed 100% specificity for detecting NoV, RVA, and HAdV, with varying sensitivity levels of 86.7% for RVA, 70.6% for NoV, and 76.2% for HAdV.
- The findings confirm that the IP-Triple I IC test kit is effective for quick detection of multiple viral genotypes in stool samples, proving valuable for timely diagnosis during outbreaks.