The association between NLGN4 gene variants and the incidence of autism spectrum disorders in Guilan, Iran.

Autism Spectrum Disorder (ASD) is a developmental disorder characterized by impaired social interaction, communication skills, and repetitive behaviours. This study aimed to investigate the association between variants of the Neuroligin-4 (NLGN4) gene (rs1882260 and rs3810688) and the incidence of ASD in North of Iran in the ASD group (n = 60) and control group (n = 60). DNA was isolated from whole blood, saliva, or hair samples.

Pharmacogenomics-Based Detection of Variants Involved in Pain, Anti-inflammatory and Immunomodulating Agents Pathways by Whole Exome Sequencing and Deep Investigations Revealed Novel Chemical Carcinogenesis and Cancer Risks.

Background: Next-Generation Sequencing (NGS) methods specifically Whole-Exome Sequencing (WES) have demonstrated promising findings with a high accuracy of 91%-99% in Pharmacogenomics (PGx). A PGx-based panel can be utilized to minimize adverse drug reactions (ADRs) and maximize the treatment efficacy. Remarkably, Cancer Pain Management (CPM) is a cutting-edge concept in modern medicine.

Prediction of treatment response and outcome of transarterial chemoembolization in patients with hepatocellular carcinoma using artificial intelligence: A systematic review of efficacy.

Purpose: To perform a systematic literature review of the efficacy of different AI models to predict HCC treatment response to transarterial chemoembolization (TACE), including overall survival (OS) and time to progression (TTP).

Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines until May 2, 2024.

Results: The systematic review included 23 studies with 4,486 HCC patients.

Dietary Patterns Among Canadian Caucasians and Their Association With Chronic Conditions.

Background: Understanding the dietary patterns of populations is crucial in addressing chronic health conditions that are influenced by diet and lifestyle. We aimed to identify the dietary patterns among adult Caucasian Canadians and examine their associations with socioeconomic and sociodemographic factors and chronic health conditions.

Methodology: We used two comprehensive national nutrition surveys: Canadian Community Health Survey (CCHS)2015 and CCHS Cycle 2.