Publications by authors named "P Kennel"
Despite advances in our understanding of myocardial recovery among left ventricular assist device (LVAD) patients, with 10-30% of patients achieving substantial myocardial improvement, the rates of LVAD support cessation remain extremely low (1-2%). These numbers are in stark contrast to clinical trial data where successful LVAD cessation is reported in up to 47% of patients. The majority of LVAD programs lack structured recovery programs and targeted protocols, likely underscoring the heterogeneity that exists among LVAD patients with myocardial recovery.
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- * LVAD support helped to normalize a small percentage (3.2%) of HF-associated DMPs, indicating limited reversibility of these epigenetic changes post-therapy.
- * A newly identified long noncoding RNA (LINC00881) showed significant hypermethylation and downregulation in HF, affecting key cardiac gene expressions; the findings suggest that further epigenetic interventions may be essential for long-term recovery from heart
Acute decompensated heart failure (ADHF) is a primary cause of older adults presenting to the emergency department with acute dyspnea. Point-of-care lung ultrasound (LUS) has shown comparable or superior diagnostic accuracy in comparison with a chest x-ray (CXR) in patients presenting with symptoms of ADHF. The systematic review and meta-analysis aimed to elucidate the sensitivity and specificity of LUS in comparison with CXR for diagnosing ADHF and summarize the rapidly growing body of evidence in this domain.
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