Publications by authors named "P Kavatzikidou"
Article Synopsis
- - The study aims to create effective scaffolds for neural tissue engineering by examining how neuronal cells react to specially patterned silicon surfaces and biodegradable materials.
- - Researchers experimented with neuro2a cells alone and alongside glial cells to understand the impacts of surface roughness on cell differentiation, noting that increased roughness hinders this process.
- - Findings emphasize the critical role of surface texture in neuronal cell growth and suggest further investigation could identify reasons for limited differentiation, helping to design better culture substrates.
Article Synopsis
- * SCs respond to their mechanical environment, with factors like material properties, elasticity, and surface texture influencing their behavior during development and injury.
- * Research on SCs' mechanobiological responses is crucial for improving scaffold designs in tissue engineering and regenerative medicine to better repair PNS injuries.
Article Synopsis
- The increasing variety of manufactured nanomaterials (MNMs) and their synthesis methods has led to potential interactions with humans and the environment, highlighting the need for understanding their properties.
- The relationship between key characteristics of MNMs—like size and surface chemistry—and their behavior in specific media is crucial for evaluating their functionality and safety.
- The review aims to establish a strategy for designing safer nanomaterials by linking their properties to functionality, ultimately minimizing health and environmental risks during the innovation process.
Although the peripheral nervous system exhibits a higher rate of regeneration than that of the central nervous system through a spontaneous regeneration after injury, the functional recovery is fairly infrequent and misdirected. Thus, the development of successful methods to guide neuronal outgrowth, in vitro, is of great importance. In this study, a precise flow controlled microfluidic system with specific custom-designed chambers, incorporating laser-microstructured polyethylene terephthalate (PET) substrates comprising microgrooves, was fabricated to assess the combined effect of shear stress and topography on Schwann cells' behavior.
View Article and Find Full Text PDFUltrafast laser processing with the formation of periodic surface nanostructures on the 15×(Ti/Zr)/Si multilayers is studied in order to the improve cell response. A novel nanocomposite structure in the form of 15x(Ti/Zr)/Si multilayer thin films, with satisfying mechanical properties and moderate biocompatibility, was deposited by ion sputtering on an Si substrate. The multilayer 15×(Ti/Zr)/Si thin films were modified by femtosecond laser pulses in air to induce the following modifications: (i) mixing of components inside of the multilayer structures, (ii) the formation of an ultrathin oxide layer at the surfaces, and (iii) surface nano-texturing with the creation of laser-induced periodic surface structure (LIPSS).
View Article and Find Full Text PDF