Publications by authors named "P Kavaliauskas"
Various cancer-associated morbidities remain a growing global health challenge, resulting in a significant burden on healthcare systems worldwide due to high mortality rates and a frequent lack of novel therapeutic options for advanced and localized disease. Reactive oxygen species (ROS) play an important role in cancer pathogenesis and response to chemotherapeutics; therefore, it is crucial to develop novel compounds with both antioxidant and anticancer activity. In this study, a series of previously reported 3-((4-hydroxyphenyl)amino)propanoic acid derivatives (compounds -) were evaluated for their anticancer and antioxidant activities.
View Article and Find Full Text PDFObjectives: The study aimed to assess the mental health and well-being of Lithuanian healthcare workers by gathering demographic information, identifying common stressors affecting the work environment, evaluating mental health, and exploring directions for psychosocial care. Additionally, the research explored the prevalence of considering a career change among respondents.
Material And Methods: The study included 1618 responders who completed an online survey in December 2021 - January 2022.
Article Synopsis
- In pulmonary mucormycosis, inhaled spores invade airway cells, with HIF1α playing a crucial role in this infection process.
- HIF1α signaling activates during infection, leading to increased expression of pro-inflammatory genes, but inhibiting it reduces fungal invasion and boosts survival in mouse models.
- The study highlights HIF1α's dual function: it aids the fungus in invading cells while also helping the host defend against the infection.