Publications by authors named "P Kasparian"

Article Synopsis
  • The study measured the levels of Trimethoprim (TMP) and Sulfamethoxazole (SMZ) in pleural effusion and plasma in 7 patients during their first, third, and fifth days of treatment.
  • The ratio of TMP in pleural fluid to plasma increased steadily, averaging 0.79 by 12 hours, while SMZ peaked at 8 hours on day one (0.53) and rose to 0.71 by day five.
  • TMP levels in pleural fluid were found to be lower than typically seen in bronchial secretions, whereas SMZ levels were significantly higher.
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The authors specify the contribution of pleural carcinoembryonic antigen (CEA) assay in the diagnosis of malignant pleuritis by comparing it to plasma concentrations and pathologic findings. 45 patients with pleuritis were studied. Etiology was malignant in 15 and non-malignant in 27.

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Pneumomediastinum is an uncommon, often overlooked, condition resulting from the rupture of perivascular alveoli and the migration of air along the pulmonary vessels. Diagnosis, which is usually difficult, rests on three major signs: cervical subcutaneous emphysema, Hamman's sign and roentgenological findings. Prognosis is good and the course is uneventful.

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The authors report a case of legionnaires' disease with retractile late sequelae affecting the lingula and the dorsal segment of the culmen. They stress the need for appropriate and prolonged treatment because of the possible presence of intracellular Legionella pneumophila. The existence of an associated staphylococcal infection is also one of the hypotheses raised in explaining such sequelae.

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Article Synopsis
  • Pulmonary biopsies were performed on 16 patients with difficult diagnostic issues using thoracoscopy.
  • The authors successfully diagnosed 14 cases involving diffuse or localized lung pathology, and these diagnoses aligned with the patients' disease progression.
  • The procedure was safe, with no major incidents reported.
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