Cancer stem cells contribute to angiogenesis and lymphangiogenesis in serous adenocarcinoma of the ovary.

The origin of blood and lymphatic vessels in high-grade serous adenocarcinoma of ovary (HGSOC) is uncertain. We evaluated the potential of cancer stem cells (CSCs) in HGSOC to contribute to their formation. Using spheroids as an in vitro model for CSCs, we have evaluated their role in primary malignant cells (PMCs) in ascites from previously untreated patients with HGSOC and cell lines.

Comparative evaluation of the fracture resistance of teeth prepared with rotary system, filled with single cone gutta-percha and laterally condensed with zinc oxide eugenol and resin based (AH26) sealers to that of Resilon.

Aim And Objective: To compare the fracture resistance of teeth prepared with rotary system and filled with single cone guttapercha followed by lateral condensation with different sealers like zinc oxide eugenol and resin based (AH26) to that of resilon.

Materials And Methods: A total number of 70 extracted intact human permanent maxillary incisors were selected. All prepared samples were divided into one control group (n = 10) and three experimental groups (n = 20 per group).

Protective effect of dendrodoine analog, an aminothiazole derivative against X-radiation induced hepatocellular damage in mice.

This study evaluated the radioprotective effect of dendrodoine analog (DA) against radiation-induced damage in the liver of mice. The study was divided into two phases; in the first phase, the effective concentration of DA was fixed by performing a survival study. In the second phase, the fixed effective concentration of DA was orally administered to mice to evaluate its radioprotective efficacy by performing various assays.

Chemopreventive potential of 18beta-glycyrrhetinic acid: an active constituent of liquorice, in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.

Chemoprevention, a useful and attractive approach in experimental oncology, helps to investigate the cancer preventive potential of natural products and synthetic entities. Present study evaluated the chemopreventive potential of glycyrrhetinic acid in 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch carcinogenesis. Oral tumor was developed in the buccal pouch of golden Syrian hamsters by painting with DMBA three times a week for 14 weeks.

Evaluating the radioprotective effect of hesperidin in the liver of Swiss albino mice.

The present study was aimed to evaluate the radioprotective efficacy of hesperidin, a flavonone glycoside against X-ray radiation-induced cellular damage in the liver of Swiss albino mice. The first phase of the study was carried out to fix the effective concentration of hesperidin by performing a 30 days of survival studies using different graded doses [12.5, 25, 50 and 100mg/kg body weight] of hesperidin administered orally to mice via intragastric intubations for seven consecutive days prior to exposure of whole body radiation (10 Gy).