Publications by authors named "P Karling"
Article Synopsis
- The study aimed to find protein signatures in blood that could help identify individuals at high risk for inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis.
- Researchers analyzed blood samples from a large population, utilizing machine-learning methods to identify and validate these protein signatures across multiple cohorts.
- A specific combination of 29 proteins was effective in differentiating preclinical CD cases from controls, achieving a high accuracy, while the prediction for ulcerative colitis was less robust but still significant.
Background: Treatments and strategies for inflammatory bowel disease (IBD) have gradually evolved in the 2000s.
Objectives: We investigated whether the prescription of corticosteroids (prednisolone and budesonide) in patients with IBD in the first 5 years after diagnosis changed in patients diagnosed between 2006 and 2018.
Design: Retrospective observational study.
Background And Aim: We aimed to investigate whether individuals with low pepsinogen I levels differed from those with normal pepsinogen I levels in terms of proton pump inhibitors (PPIs) use, referral to gastroscopy, and findings on gastroscopy.
Methods: Serum pepsinogen I was measured in 518 persons (mean age 51.6, SD 8.
Introduction: The clinical consequences for patients with inflammatory bowel disease (IBD) who stop treatment owing to side effects have not been fully investigated.
Methods: This retrospective observational study aimed to compare patients who discontinued thiopurine treatment due to side effects with those who tolerated thiopurine treatment in the use of other IBD drugs, surgery, and fecal calprotectin values in the first 5 years after the start of thiopurine treatment.
Results: The proportion of patients with IBD who initiated thiopurine treatment at our clinic was 44% (32% ulcerative colitis and 64% Crohn's disease) and 31% ( = 94) of those patients had to stop thiopurine treatment within 5 years due to side effects.
Background: Smoking and the use of non-steroidal anti-inflammatory drugs (NSAIDs) acetylsalicylic acid (ASA), proton pump inhibitors (PPIs), serotonin reuptake inhibitors (SSRIs), and statins have been associated with microscopic colitis (MC).
Objectives: We investigated whether these factors were associated with repeated budesonide treatments in patients diagnosed with MC.
Design: Retrospective observational study.