Publications by authors named "P Kaposi-Novak"
Article Synopsis
- Claudins are proteins that play a role in cancer development, particularly in hepatocellular carcinoma (HCC), and are regulated differently in various malignancies.
- The study focused on measuring claudin expressions (specifically -1, -2, -3, -4, and -7) in liver tissues from patients with HCC, cirrhosis, and healthy controls, finding that claudin-1 and -7 levels were higher in cirrhotic tissues.
- The results indicated that while cirrhosis is associated with increased claudin-1 expression, HCV infection alone doesn't significantly affect claudin levels, suggesting that changes in claudin expression are more linked to cirrhos
Article Synopsis
- The study aimed to evaluate disease progression and the effectiveness of various assessment methods in patients with polymyalgia rheumatica (PMR) over a 26-week period.
- Eighty-five patients starting treatment with prednisone were monitored for pain, inflammation, and quality of life through clinical exams, laboratory tests, and ultrasound evaluations.
- Results indicated that most patients improved significantly with corticosteroid treatment, and certain ultrasound findings could help predict this response; thus, incorporating specific patient-reported outcomes and inflammatory markers is recommended for better assessment in clinical settings.
Article Synopsis
- - The study aimed to create classification criteria for polymyalgia rheumatica (PMR) that could help differentiate it from similar conditions, using a sample of 125 PMR patients and 169 non-PMR subjects over six months.
- - A scoring system was developed based on specific symptoms, such as morning stiffness and hip pain, with a score of 4 or higher indicating a strong likelihood of PMR, while incorporating ultrasound increased accuracy further.
- - The provisional criteria suggest that patients over 50 with certain symptoms and no alternative diagnosis can be classified as having PMR, but these criteria are intended for classification, not for diagnosis.
Article Synopsis
- - The study aimed to create new classification criteria for polymyalgia rheumatica (PMR) through a cohort of 125 patients with PMR and 169 individuals with similar conditions for comparison.
- - A scoring system was developed based on symptoms like morning stiffness, hip pain, and absence of certain antibodies, achieving a score ≥4 with 68% sensitivity and 78% specificity for identifying PMR.
- - The criteria suggest that patients over 50 with specific symptoms, including bilateral shoulder pain and elevated inflammatory markers, might be classified as having PMR, but these criteria are not intended for making a diagnosis.
HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during liver regeneration. HGF treatment accelerates resolution of fibrosis in experimental animal models. Here, we utilized Met(fl/fl);Alb-Cre(+/-) conditional knockout mice and a carbon tetrachloride(CCl(4))-induced liver fibrosis model to formally address the role of c-Met signaling in hepatocytes in the context of chronic tissue injury.
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