Publications by authors named "P Kamboj"
Article Synopsis
- Psoriatic arthritis (PsA) often develops in patients with psoriasis, and early detection is crucial for better outcomes, making screening essential.
- A study conducted at Armed Forces Medical College examined 117 chronic plaque psoriasis patients without visible arthritis using high-frequency ultrasound, revealing common issues like synovial thickening in the distal interphalangeal joint and Achilles tendon.
- While the study shows the effectiveness of ultrasound in identifying subclinical PsA, its cross-sectional design and lack of matched controls highlight the need for future longitudinal studies for more comprehensive understanding and validation.
Paradoxical eczema in psoriasis patients following treatment with secukinumab.
Indian J Dermatol Venereol Leprol
September 2024
Quinoxaline molecule has gathered a great attention in medicinal chemistry due to its vide spectrum of biological activities and emerged as a versatile pharmacophore in drug discovery and development. Its structure comprises bicyclic ring of benzopyrazine and displays a range of pharmacological properties including antibacterial, antifungal, antiviral, anticancer and anti-inflammatory. This review summarizes the different strategies for the synthesis of quinoxalines and their anti-inflammatory properties acting through different mechanisms.
View Article and Find Full Text PDFA new series of imidazothiazole derivatives bearing thiazolidinone moiety (4a-g and 5a-d) were designed, synthesized and evaluated for potential epidermal growth factor receptor (EGFR) kinase inhibition, anticancer and anti-inflammatory activity, cardiomyopathy toxicity and hepatotoxicity. Compound 4c inhibited EGFR kinase at a concentration of 18.35 ± 1.
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