Fluorophore-quencher complexes (Cu/Al) of coumarin Schiff bases as chemosensors for the detection of L-glutamic acid and L-arginine: and studies.

This study reports the development of new probes RR1 ((1)-1-(1-(6-bromo-2-oxo-2-chromen-3-yl)ethylidene)ethyl thiosemicarbazone) and RR2 ((1)-1-(1-(6-bromo-2-oxo-2-chromen-3-yl)ethylidene)phenyl thiosemicarbazone), which selectively showed fluorescence turn 'OFF' response towards Cu and Al. Further, complexes of RR1-Cu2+ and RR2-Al3+ acted as chemosensors for the detection of L-amino acids. RR1-Cu2+ selectively detected L-arginine (fluorescence turn 'ON'), and RR2-Al3+ selectively detected L-glutamic acid (fluorescence turn 'ON').

Phytosome Technology: A Novel Breakthrough for the Health Challenges.

Phytochemicals are compounds found in plants that have various biological activities and health benefits. Although phytochemicals have diverse therapeutic applications, they confront several challenges, such as poor solubility, instability, and low bioavailability. Phytosomes are used to overcome those challenges.

Preparation of new organo-ruthenium(II) complexes and their nucleic acid/albumin binding efficiency and cytotoxicity studies.

Hetero-bimetallic ruthenium(II) complexes (PRAFIZ and PRBFIZ) containing acetyl ferrocene (AFIZ)/benzoyl ferrocene isonicotinic hydrazone ligands (BFIZ) were synthesized and characterized by various spectral and analytical techniques. The structure of acetyl ferrocene isonicotinic hydrazone (AFIZ) and the complex PRBFIZ was confirmed by X-ray crystallography. The hydrazide ligands coordinated in a bidentate monobasic fashion using their N1 hydrazinic nitrogen and enolic oxygen atoms.

Mutagenicity and safety evaluation of Ashwagandha () root aqueous extract in different models.

(Ashwagandha) also called as Indian ginseng, a revered herb from Indian traditional system of medicine is a rejuvenator and tonic () used for its varied benefits. The roots of ashwagandha exhibit properties like anti-inflammatory, aphrodisiac, anthelmintic, astringent, diuretic, stimulant and thermogenic. However, data of ashwagandha on its mutagenic effects are lacking.

Ninety-day repeated dose toxicity of Ashwagandha (Withania somnifera) root extract in Wistar rats.

Many pharmacological studies have been carried out to describe multiple biological properties of Ashwagandha (Withania somnifera) and the additional safety information on repeated dose toxicity is limited. Therefore, the aim of this study was to obtain safety data for KSM-66 Ashwagandha Root Extract (ARE) through repeated-dose toxicity in Wistar rats according to the Organisation for Economic Co-operation and Development (OECD) test guideline (TG 408). ARE was orally administered to rats at doses of 0, 500, 1000, and 2000 mg/kg body weight/day for 90-day and reversibility of effects of 0 and 2000 mg/kg body weight/day was assessed for 14 days.