Publications by authors named "P Kalab"
TDP-43 nuclear clearance and cytoplasmic aggregation are hallmarks of TDP-43 proteinopathies. We recently demonstrated that binding to endogenous nuclear GU-rich RNAs sequesters TDP-43 in the nucleus by restricting its passive nuclear export. Here, we tested the feasibility of synthetic RNA oligonucleotide-mediated augmentation of TDP-43 nuclear localization.
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- Cells use mechanosensors on their surface and inside to detect physical and geometric signals from their environment, particularly through mechanosensitive ion channels (MICs).
- The nucleus acts not only as a protector of genetic material but also as a sensor that responds to physical features in tissue, influencing how cells migrate.
- The review emphasizes the complex interactions between nuclear transport and ion transport during cell migration, highlighting the need to understand how these mechanisms work together for better insights into cell movement in various conditions.
Article Synopsis
- Cells in confined spaces face mechanical challenges that impact their migration, but the exact effects on their migration machinery are not fully understood.
- Research shows that a protein called anillin, which regulates cytokinesis, is retained in the cytoplasm during interphase and is recruited to the edges of cells when they migrate in confined environments.
- Anillin works alongside another protein, Ect2, to enhance muscle contractility inside cells, which is crucial for effective invasion and movement in cancer progression.
TDP-43 nuclear clearance and cytoplasmic aggregation are hallmarks of TDP-43 proteinopathies. We recently demonstrated that binding to endogenous nuclear GU-rich RNAs sequesters TDP-43 in the nucleus by restricting its passive nuclear export. Here, we tested the feasibility of synthetic RNA oligonucleotide-mediated augmentation of TDP-43 nuclear localization.
View Article and Find Full Text PDFCells tune adherens junction dynamics to regulate epithelial integrity in diverse (patho)physiological processes, including cancer metastasis. We hypothesized that the spatially confining architecture of peritumor stroma promotes metastatic cell dissemination by remodeling cell-cell adhesive interactions. By combining microfluidics with live-cell imaging, FLIM/FRET biosensors, and optogenetic tools, we show that confinement induces leader cell dissociation from cohesive ensembles.
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