Publications by authors named "P KIRKPATRICK"
Article Synopsis
- Huntington's disease is a neurodegenerative disorder caused by a mutation in the huntingtin protein, leading to symptoms like chorea and cognitive decline due to neuronal death.
- Recent research highlights the importance of the neurovascular unit in understanding the disease, particularly the effects of the mutant huntingtin protein on brain function.
- A study compared presymptomatic and symptomatic Huntington's disease patients to healthy controls, revealing reduced neurovascular phase coherence and lower efficiency of oxygen transport to the brain, indicating impaired neurovascular function in both patient groups.
Objective: For patients with aneurysmal subarachnoid hemorrhage (aSAH) in whom endovascular treatment is not the optimal treatment strategy, microsurgical clipping remains a viable option. We examined changes in morbidity and outcome over time in patients treated surgically and in relation to surgeon volume and experience.
Methods: All patients who underwent microsurgery for aSAH from 2007 to 2019 at our institution were included.
Evaluation of Outcomes Among Patients With Traumatic Intracranial Hypertension Treated With Decompressive Craniectomy vs Standard Medical Care at 24 Months: A Secondary Analysis of the RESCUEicp Randomized Clinical Trial.
JAMA Neurol
July 2022
Importance: Trials often assess primary outcomes of traumatic brain injury at 6 months. Longer-term data are needed to assess outcomes for patients receiving surgical vs medical treatment for traumatic intracranial hypertension.
Objective: To evaluate 24-month outcomes for patients with traumatic intracranial hypertension treated with decompressive craniectomy or standard medical care.
Objectives: Mixed methods systematic reviews (MMSRs) combine quantitative and qualitative evidence within a single review. Since the revision of the JBI methodology for MMSRs in 2020, there has been an increasing number of reviews published that claim to follow this approach. A preliminary examination of these indicated that authors frequently deviated from the methodology.
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