Publications by authors named "P K Zahn"
BLOOD PROTEOMICS AND MULTIMODAL RISK PROFILING of human volunteers after incision injury: a translational study for advancing Personalized Pain Management After Surgery.
Pharmacol Res
January 2025
Article Synopsis
- A significant number of patients experience chronic pain after surgery, highlighting the urgent need for predictive models that consider bio-psycho-social and physiological factors.
- A study involving male volunteers assessed pain characteristics, psychological factors, and blood proteomics before and after an experimental incision to predict outcomes related to pain intensity and hyperalgesia.
- The results revealed that a combination of diverse parameters could predict pain responses more accurately than single features, identified specific protein signatures associated with inflammation, and suggested repurposing existing medications for better pain management.
Background: Cardiopulmonary bypass (CPB) triggers marked cytokine release often followed by a systemic inflammatory response syndrome, associated with adverse postoperative outcomes. This trial investigates the intraoperative use of haemoadsorption (HA) during cardiac surgery with CPB to assess its impact on postoperative systemic inflammatory response.
Methods: In this prospective randomised controlled trial (ethics approval no.
Remote ischemic preconditioning (RIPC) reduces ischemia-reperfusion injury in aortocoronary bypass surgery, potentially via extracellular vesicles (EVs) and their micro-RNA content. Clinical data implicate that propofol might inhibit the cardioprotective RIPC effect. This prospective, randomized study investigated the influence of different anesthetic regimes on RIPC efficacy and EV micro-RNA signatures.
View Article and Find Full Text PDFBackground: The limb symmetry index (LSI) is a metric of strength restoration. It is key to successfully return to sports after anterior cruciate ligament (ACL) reconstruction. The threshold for return to sports is generally considered an LSI of ≥85%.
View Article and Find Full Text PDFThe inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain perception. However, in post-surgical pain, the exact mechanism and modes of action of GABAergic transmission have been poorly studied. This work aimed to investigate GABA synthesis and uptake in the incisional pain model in a time-dependent manner.
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