Fibrolipomatous Hamartoma of Median Nerve - A Diagnostic Challenge.

Introduction: Fibrolipomatous hamartoma (FLH) is an uncommon slow-growing tumor of benign etiology, which predominantly affects the median nerve.

Case Report: We report the case study of a 17-year-old male patient, who presented with complaints of a gradually increasing localized swelling over the volar aspect of left hand for 1 year. A contrast-enhanced Magnetic resonance (MR) scan of the left hand was performed which demonstrated characteristic findings.

Signal parameter estimation of complex exponentials using fourth order statistics: additive Gaussian noise environment.

A novel approach based on fourth order statistics is presented for estimating the parameters of the complex exponential signal model in additive colored Gaussian noise whose autocorrelation function is not known. Monte Carlo simulations demonstrate that the proposed method performs better than an existing method which also utilizes fourth order statistics under the similar noise condition. To deal with the non-stationarity of the modeled signal, various concepts are introduced while extending the estimation technique based on linear prediction to the higher order statistics domain.

Signal parameter estimation using fourth order statistics: multiplicative and additive noise environment.

Parameter estimation of various multi-component stationary and non-stationary signals in multiplicative and additive noise is considered in this paper. It is demonstrated that the parameters of complex sinusoidal signal, complex frequency modulated (FM) sinusoidal signal and complex linear chirp signal in presence of additive and multiplicative noise can be estimated using a new definition of the fourth order cumulant (FOC), and the computed accumulated FOC (AFOC). Analytical expressions for the FOC/AFOC of the above signals are derived.

Systemic vaccination induces clonally diverse SIV-specific CD8+ T-cell populations in systemic and mucosal compartments.

An HIV-1 vaccine must elicit a clonally diverse virus-specific CD8+ T-cell response to contain mutant virus forms, and these responses must be present in mucosal tissues, which are the site of early HIV-1 replication. We show that systemic delivery of prototype vaccine vectors in rhesus monkeys induced SIV (simian immunodeficiency virus)-specific CD8+ T-cell responses in systemic and mucosal compartments with comparable clonal compositions. Although clonal sharing was maintained between the peripheral blood and lungs, the clonal constituents of the vaccine-induced CD8+ T-cell populations in the gastrointestinal mucosal tissues evolved away from the peripheral blood population.

Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys.

Breast milk transmission of HIV remains an important mode of infant HIV acquisition. Enhancement of mucosal HIV-specific immune responses in milk of HIV-infected mothers through vaccination may reduce milk virus load or protect against virus transmission in the infant gastrointestinal tract. However, the ability of HIV/SIV strategies to induce virus-specific immune responses in milk has not been studied.